Of drugs and trypanosomatids: new tools and knowledge to reduce bottlenecks in drug discovery
A Bhattacharya, A Corbeil, RL do Monte-Neto… - Genes, 2020 - mdpi.com
Leishmaniasis (Leishmania species), sleeping sickness (Trypanosoma brucei), and Chagas
disease (Trypanosoma cruzi) are devastating and globally spread diseases caused by …
disease (Trypanosoma cruzi) are devastating and globally spread diseases caused by …
Anti-trypanosomatid drug discovery: progress and challenges
Leishmaniasis (visceral and cutaneous), Chagas disease and human African
trypanosomiasis cause substantial death and morbidity, particularly in low-and middle …
trypanosomiasis cause substantial death and morbidity, particularly in low-and middle …
Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need
The WHO recognizes human African trypanosomiasis, Chagas disease and the
leishmaniases as neglected tropical diseases. These diseases are caused by parasitic …
leishmaniases as neglected tropical diseases. These diseases are caused by parasitic …
The current drug discovery landscape for trypanosomiasis and leishmaniasis: Challenges and strategies to identify drug targets
F Altamura, R Rajesh, CMC Catta‐Preta… - Drug development …, 2022 - Wiley Online Library
Human trypanosomiasis and leishmaniasis are vector‐borne neglected tropical diseases
caused by infection with the protozoan parasites Trypanosoma spp. and Leishmania spp …
caused by infection with the protozoan parasites Trypanosoma spp. and Leishmania spp …
Complementary medicinal chemistry-driven strategies toward new antitrypanosomal and antileishmanial lead drug candidates
Trypanosomiases and Leishmaniases are neglected tropical diseases that affect the less
developed countries. For this reason, they did not and still do not have high visibility in …
developed countries. For this reason, they did not and still do not have high visibility in …
Accelerating drug discovery efforts for trypanosomatidic infections using an integrated transnational academic drug discovery platform
According to the World Health Organization, more than 1 billion people are at risk of or are
affected by neglected tropical diseases. Examples of such diseases include …
affected by neglected tropical diseases. Examples of such diseases include …
Chemogenomics and parasitology: small molecules and cell-based assays to study infectious processes
MAT Muskavitch, N Barteneva… - … Chemistry & High …, 2008 - ingentaconnect.com
Infectious diseases caused by protozoan parasites-malaria, sleeping sickness,
leishmaniasis, Chagas' disease, toxoplasmosis-remain chronic problems for humanity. We …
leishmaniasis, Chagas' disease, toxoplasmosis-remain chronic problems for humanity. We …
An overview on target-based drug design against kinetoplastid protozoan infections: Human African trypanosomiasis, Chagas disease and leishmaniases
V Kourbeli, E Chontzopoulou, K Moschovou, D Pavlos… - Molecules, 2021 - mdpi.com
The protozoan diseases Human African Trypanosomiasis (HAT), Chagas disease (CD), and
leishmaniases span worldwide and therefore their impact is a universal concern. The …
leishmaniases span worldwide and therefore their impact is a universal concern. The …
Repurposing of the open access malaria box for kinetoplastid diseases identifies novel active scaffolds against trypanosomatids
M Kaiser, L Maes, LP Tadoori… - Journal of …, 2015 - journals.sagepub.com
Phenotypic screening had successfully been used for hit generation, especially in the field of
neglected diseases, in which feeding the drug pipeline with new chemotypes remains a …
neglected diseases, in which feeding the drug pipeline with new chemotypes remains a …
Novel compounds to combat trypanosomatid infections: a medicinal chemical perspective
M González, H Cerecetto - Expert Opinion on Therapeutic Patents, 2011 - Taylor & Francis
Introduction: The current therapeutic arsenal against the kinetoplastids Trypanosoma brucei,
Trypanosoma cruzi and Leishmania spp. is clearly inadequate and underscores the urgent …
Trypanosoma cruzi and Leishmania spp. is clearly inadequate and underscores the urgent …