Of drugs and trypanosomatids: new tools and knowledge to reduce bottlenecks in drug discovery

A Bhattacharya, A Corbeil, RL do Monte-Neto… - Genes, 2020 - mdpi.com
Leishmaniasis (Leishmania species), sleeping sickness (Trypanosoma brucei), and Chagas
disease (Trypanosoma cruzi) are devastating and globally spread diseases caused by …

Anti-trypanosomatid drug discovery: progress and challenges

M De Rycker, S Wyllie, D Horn, KD Read… - Nature Reviews …, 2023 - nature.com
Leishmaniasis (visceral and cutaneous), Chagas disease and human African
trypanosomiasis cause substantial death and morbidity, particularly in low-and middle …

Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need

MC Field, D Horn, AH Fairlamb… - Nature Reviews …, 2017 - nature.com
The WHO recognizes human African trypanosomiasis, Chagas disease and the
leishmaniases as neglected tropical diseases. These diseases are caused by parasitic …

The current drug discovery landscape for trypanosomiasis and leishmaniasis: Challenges and strategies to identify drug targets

F Altamura, R Rajesh, CMC Catta‐Preta… - Drug development …, 2022 - Wiley Online Library
Human trypanosomiasis and leishmaniasis are vector‐borne neglected tropical diseases
caused by infection with the protozoan parasites Trypanosoma spp. and Leishmania spp …

Complementary medicinal chemistry-driven strategies toward new antitrypanosomal and antileishmanial lead drug candidates

A Cavalli, F Lizzi, S Bongarzone, F Belluti… - FEMS Immunology & …, 2010 - academic.oup.com
Trypanosomiases and Leishmaniases are neglected tropical diseases that affect the less
developed countries. For this reason, they did not and still do not have high visibility in …

Accelerating drug discovery efforts for trypanosomatidic infections using an integrated transnational academic drug discovery platform

CB Moraes, G Witt, M Kuzikov… - … Life Sciences R&D, 2019 - journals.sagepub.com
According to the World Health Organization, more than 1 billion people are at risk of or are
affected by neglected tropical diseases. Examples of such diseases include …

Chemogenomics and parasitology: small molecules and cell-based assays to study infectious processes

MAT Muskavitch, N Barteneva… - … Chemistry & High …, 2008 - ingentaconnect.com
Infectious diseases caused by protozoan parasites-malaria, sleeping sickness,
leishmaniasis, Chagas' disease, toxoplasmosis-remain chronic problems for humanity. We …

An overview on target-based drug design against kinetoplastid protozoan infections: Human African trypanosomiasis, Chagas disease and leishmaniases

V Kourbeli, E Chontzopoulou, K Moschovou, D Pavlos… - Molecules, 2021 - mdpi.com
The protozoan diseases Human African Trypanosomiasis (HAT), Chagas disease (CD), and
leishmaniases span worldwide and therefore their impact is a universal concern. The …

Repurposing of the open access malaria box for kinetoplastid diseases identifies novel active scaffolds against trypanosomatids

M Kaiser, L Maes, LP Tadoori… - Journal of …, 2015 - journals.sagepub.com
Phenotypic screening had successfully been used for hit generation, especially in the field of
neglected diseases, in which feeding the drug pipeline with new chemotypes remains a …

Novel compounds to combat trypanosomatid infections: a medicinal chemical perspective

M González, H Cerecetto - Expert Opinion on Therapeutic Patents, 2011 - Taylor & Francis
Introduction: The current therapeutic arsenal against the kinetoplastids Trypanosoma brucei,
Trypanosoma cruzi and Leishmania spp. is clearly inadequate and underscores the urgent …