Diabetes is associated with endothelial dysfunction and increased risk of hypertension,
cardiovascular disease, and renal complications. Earlier studies have revealed that …

Nitric oxide (NO) plays an important role in the regulation of vascular tone, and evidence
suggests that endothelial-dependent relaxation, possibly mediated via NO, is impaired in …

Background—The vasodilatory effect of insulin can be acute or increase with time from 1 to 7
hours, suggesting that insulin may enhance the expression of endothelial nitric oxide …

Background Hyperglycemia is a primary cause of premature vascular disease. Endothelial
cell dysfunction characterized by diminished endothelium-dependent relaxations is likely to …

There is some evidence that the endothelium dependent vasodilatation of coronary arteries
is impaired in both types of diabetes. The underlying mechanisms are not yet clear, in …

Hyperglycemia is considered a primary cause of diabetic vascular complications. A hallmark
of vascular disease is endothelial cell dysfunction characterized by diminished nitric-oxide …

Several studies suggest that nitric oxide (NO) production is reduced in diabetes and that the
decrease of NO may be related to the pathogenesis of diabetic endothelial damage. NO …

Hypertension and diabetes mellitus are associated with accelerated atherosclerosis and an
increased prevalence of cardiovascular disease. Loss of the modulatory role of the …

Insulin-induced vasodilatation in vivo has been attributed to the activation of the endothelial
nitric oxide (NO) synthase (eNOS). The present study addressed the effects of insulin on the …

Conclusion. Collectively, these studies suggest that endothelial dysfunction (1) is not unique
to chemically induced experimental models of IDDM,(2) is found in both conduit and …