Mycobacterium tuberculosis: immune response, biomarkers, and therapeutic intervention

L Zhuang, L Yang, L Li, Z Ye, W Gong - MedComm, 2024 - Wiley Online Library
Although tuberculosis (TB) is an infectious disease, the progression of the disease following
Mycobacterium tuberculosis (MTB) infection is closely associated with the host's immune …

[HTML][HTML] Understanding the reciprocal interplay between antibiotics and host immune system: how can we improve the anti-mycobacterial activity of current drugs to …

HE Park, W Lee, MK Shin, SJ Shin - Frontiers in Immunology, 2021 - frontiersin.org
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb) infection, remains a global
health threat despite recent advances and insights into host-pathogen interactions and the …

Mycobacterium tuberculosis: Pathogenesis and therapeutic targets

J Yang, L Zhang, W Qiao, Y Luo - MedComm, 2023 - Wiley Online Library
Tuberculosis (TB) remains a significant public health concern in the 21st century, especially
due to drug resistance, coinfection with diseases like immunodeficiency syndrome (AIDS) …

For better or for worse: the immune response against Mycobacterium tuberculosis balances pathology and protection

A Dorhoi, ST Reece, SHE Kaufmann - Immunological reviews, 2011 - Wiley Online Library
Tuberculosis (TB) is a complex disease, and the success of the bacterium as an intracellular
pathogen is the outcome of its close and longstanding coevolution with the mammalian host …

Overcoming the global crisis:“yes, we can”, but also for TB…?

THM Ottenhoff - European journal of immunology, 2009 - Wiley Online Library
Tuberculosis (TB) poses formidable challenges to global health at the public health‐,
scientific‐and political level. Causing almost two million deaths every year, this ancient …

[HTML][HTML] It takes a village: the multifaceted immune response to Mycobacterium tuberculosis infection and vaccine-induced immunity

SE Larsen, BD Williams, M Rais, RN Coler… - Frontiers in …, 2022 - frontiersin.org
Despite co-evolving with humans for centuries and being intensely studied for decades, the
immune correlates of protection against Mycobacterium tuberculosis (Mtb) have yet to be …

Host-directed therapies to combat tuberculosis and associated non-communicable diseases

P Baindara - Microbial pathogenesis, 2019 - Elsevier
Mycobacterium tuberculosis (Mtb) has coevolved with a human host to evade and exploit the
immune system in multiple ways. Mtb is an enormously successful human pathogen that can …

Mycobacterium tuberculosis

YY Li, RJ Cai, EA Talbot, YT Wang - Molecular Medical Microbiology, 2024 - Elsevier
Mycobacterium tuberculosis is the causative pathogen of tuberculosis (TB), an ancient
disease that continues to tremendously impact global human health. Rapid and accurate …

Innate Immunity Holding the Flanks until Reinforced by Adaptive Immunity against Mycobacterium tuberculosis Infection

N Khan, A Vidyarthi, S Javed, JN Agrewala - Frontiers in microbiology, 2016 - frontiersin.org
T cells play a cardinal role in imparting protection against Mycobacterium tuberculosis (Mtb).
However, ample time is required before T-cells are able to evoke efficient effector responses …

[HTML][HTML] Approaches to Address Resistance, Drug Discovery, and Vaccine Development in Mycobacterium tuberculosis: Challenges and Opportunities

S Sharma, D Sharma, NP Kalia - Frontiers in Microbiology, 2022 - frontiersin.org
Mycobacterium tuberculosis (Mtb), a causative microorganism for tuberculosis (TB), is
considered to be a leading cause of mortality and morbidity around the globe. According to …