Hypoxia-inducible factor-1 (HIF-1) has been shown to mediate the transcriptional activation
of its target genes in response to oxygen concentration, most likely via a pathway involving a …

Recent studies of tissue culture cells have defined a widespread system of oxygen-
regulated gene expression based on the activation of a heterodimeric transcription factor …

Abstract Hypoxia-inducible factor 1 (HIF-1) mediates transcriptional responses to hypoxia.
HIF-1 is composed of an O2-and growth factor-regulated HIF-loc subunit and a constitutively …

Hypoxia-inducible factor 1 (HIF-1) is a transcriptional activator that functions as a master
regulator of O2 homeostasis. HIF-1 target genes encode proteins that increase O2 delivery …

ABSTRACT A great many aspects of the anatomy and physiology of large animals are
constrained by the need to match oxygen supply to cellular metabolism and appear likely to …

The maintenance of oxygen homeostasis is required both in physiological development and
tumour growth. Hypoxia inducible factor (HIF) plays a central role in both processes …

Tumor hypoxia is a feature common to almost all solid tumors due to malformed vasculature
and inadequate perfusion. Tumor cells have evolved mechanisms that allow them to …

The hypoxia-inducible transcription factors (HIFs) play a central role in the response of cells
to hypoxia. HIFs are αβ dimers, the human α subunit having three isoforms. HIF-3α is unique …

Hypoxia-inducible factors (HIFs) are essential mediators of the cellular oxygen-signaling
pathway. They are heterodimeric transcription factors consisting of an oxygen-sensitive …

For most organisms oxygen is essential for life. When oxygen levels drop below those
required to maintain the minimum physiological oxygen requirement of an organism or …