A delicate balance: Iron metabolism and diseases of the brain

D Hare, S Ayton, A Bush, P Lei - Frontiers in aging neuroscience, 2013 - frontiersin.org
Iron is the most abundant transition metal within the brain, and is vital for a number of
cellular processes including neurotransmitter synthesis, myelination of neurons, and …

Iron in the brain: an important contributor in normal and diseased states

DJ Piñero, JR Connor - The Neuroscientist, 2000 - journals.sagepub.com
Iron is essential for normal neurological function because of its role in oxidative metabolism
and because it is a cofactor in the synthesis of neurotransmitters and myelin. In the past …

Iron and neurodegenerative disorders

KJ Thompson, S Shoham, JR Connor - Brain research bulletin, 2001 - Elsevier
The brain shares with other organs the need for a constant and readily available supply of
iron and has a similar array of proteins available to it for iron transport, storage, and …

Iron neurochemistry in Alzheimer's disease and Parkinson's disease: targets for therapeutics

AA Belaidi, AI Bush - Journal of neurochemistry, 2016 - Wiley Online Library
Brain iron homeostasis is increasingly recognized as a potential target for the development
of drug therapies for aging‐related disorders. Dysregulation of iron metabolism associated …

Brain iron metabolism, redox balance and neurological diseases

G Gao, L You, J Zhang, YZ Chang, P Yu - Antioxidants, 2023 - mdpi.com
The incidence of neurological diseases, such as Parkinson's disease, Alzheimer's disease
and stroke, is increasing. An increasing number of studies have correlated these diseases …

Brain iron homeostasis and neurodegenerative disease

EE Benarroch - Neurology, 2009 - AAN Enterprises
Iron is essential for multiple functions in the CNS, including DNA synthesis, gene
expression, myelination, neurotransmission, and mitochondrial electron transport. Several …

Brain iron metabolism and neurodegenerative disorders

JC Sipe, P Lee, E Beutler - Developmental neuroscience, 2002 - karger.com
Iron, an essential element for central nervous system (CNS) function, has frequently been
found to accumulate in brain regions that undergo degeneration in neurological diseases …

Iron in neurodegeneration–cause or consequence?

A Ndayisaba, C Kaindlstorfer… - Frontiers in neuroscience, 2019 - frontiersin.org
Iron dyshomeostasis can cause neuronal damage to iron-sensitive brain regions.
Neurodegeneration with brain iron accumulation reflects a group of disorders caused by iron …

Iron in neuronal function and dysfunction

GA Salvador - BioFactors, 2010 - Wiley Online Library
Iron (Fe) is an essential element for many metabolic processes, serving as a cofactor for
heme and nonheme proteins. Cellular iron deficiency arrests cell growth and leads to cell …

Brain iron metabolism and CNS diseases

A Thirupathi, YZ Chang - Brain Iron Metabolism and CNS Diseases, 2019 - Springer
Iron is the most abundant trace element in the human body. It is well known that iron is an
important component of hemoglobin involved in the transport of oxygen. As a component of …