Osteosarcoma is the most common primary bone malignancy, often detected in children and
adolescents and commonly associated with TP53 alterations along with a high number of …

In this Update, the cytogenetic and molecular genetic findings in osteosarcoma (OS) and
some related tumors published since our book appeared in 1994 [1] will be presented and …

Osteosarcoma is a primary bone malignancy with a particularly high incidence rate in
children and adolescents relative to other age groups. The etiology of this often aggressive …

Pediatric osteosarcoma is characterized by multiple somatic chromosomal lesions, including
structural variations (SVs) and copy number alterations (CNAs). To define the landscape of …

Tumor-specific chromosomal abnormalities have been shown to characterize certain
subgroups of mesenchymal neoplasms. Identification of these abnormalities has proven …

Osteosarcoma is a relatively uncommon malignancy with about 1000 new cases diagnosed
each year in the United States. It is, however, among the most common nonhematologic …

Background Osteosarcoma is a highly malignant bone neoplasm of children and young
adults. It is characterized by extremely complex karyotypes and high frequency of …

Despite the knowledge of many of the genetic alterations present in osteosarcoma, its
complexity precludes placing its biology into a simple conceptual framework. In contrast to …

Despite being the most common childhood bone tumor, the genomic characterization of
osteosarcoma remains incomplete. In particular, very few osteosarcoma metastases have …

Osteosarcoma is the most common primary malignancy of bone. Most cases are sporadic
without a known genetic or environmental cause. Heritable genetic predisposition …