Mitochondria are well known as 'the powerhouses of the cell'. Indeed, their major role is
cellular energy production driven by both mitochondrial and nuclear DNA. Such a feature …

Mitochondria are the key regulators of multiple vital cellular processes, including apoptosis,
calcium homeostasis, and the generation of ATP via the metabolic pathway known as …

With the nucleus as an exception, mitochondria are the only animal cell organelles
containing their own genetic information, called mitochondrial DNA (mtDNA). During oocyte …

It is likely that there is an association between the fitness of mitochondria and their ability to
support normal cellular function. Oocytes are greatly enriched in the number of mitochondria …

The role of mitochondria as a nexus of developmental regulation in mammalian oogenesis
and early embryogenesis is emerging from basic research in model species and from …

Oocyte quality has long been considered as a main limiting factor for in vitro fertilization
(IVF). In the past decade, extensive observations demonstrated that the mitochondrion plays …

Purpose The number of women attempting to conceive between the ages of 36 and 44 has
increased significantly in the last decade. While it is well established that women's …

The oocyte is the largest cell found in multicellular organisms. Mitochondria, as the energy
factories for cells, are found in high numbers in oocytes, as they provide the energy for …

BACKGROUND There is a great inter-individual variability of ovarian ageing, and almost
20% of patients consulting for infertility show signs of premature ovarian ageing. This …

This review examines the place of mitochondria in the life cycle through oogenesis,
ovulation and early embryogenesis. Mitochondria are semi-autonomous organelles …