The objective of this work was to determine the role of mitochondria in the loss of oocyte
quality with maternal aging. Our results show that mitochondrial DNA (mtDNA) copy number …

Mitochondria affect numerous aspects of mammalian reproduction. We investigated whether
the decrease in oocyte quality associated with aging is related to altered mitochondria …

Mammalian oocytes and early cleavage-stage embryos are critically dependent on their~
100,000 mitochondria to develop from ovulation to compacted morula stage. They rely …

Mitochondria play a vital role in the metabolism of energy-containing compounds in the
oocyte cytoplasm to provide adenosine trisphosphate for fertilization and preimplantation …

Oocytes from aging ovaries contain mitochondria with morphological and genetic flaws. How
these flaws relate to phenotypes of oocyte developmental compromise associated with …

Germinal vesicle transplantation (GVT) has been proposed as a possible treatment to
correct age-related oocyte aneuploidy caused by dysfunctional ooplasm. How healthy …

Mitochondrial dysfunction is implicated in disease and age-related infertility. Mitochondrial
replacement therapies (MRT) in oocytes or zygotes, such as pronuclear (PNT), spindle (ST) …

Ovarian aging leads to a decrease in the quantity and quality of oocytes. Aged oocytes have
significantly reduced amounts of mitochondria, the energy factories of cells, leading to lower …

Mitochondria are highly dynamic organelles and their distribution, structure and activity
affect a wide range of cellular functions. Mitochondrial membrane potential (∆ Ψm) is an …

Mitochondria are fundamental organelles in eukaryotic cells that provide ATP through
oxidative phosphorylation. During this process, reactive oxygen species (ROS) are …