As women delay childbearing because of demographic and socioeconomic trends,
reproductive aging and ensuing ovarian dysfunction become increasingly more prevalent …

In mammals, mitochondria and mitochondrial DNA (mtDNA) are transmitted through the
female germ line. Mature oocytes contain at least 100,000 copies of mtDNA, organized at 1 …

Mitochondria play a primary role in cellular energetic metabolism, homeostasis, and death.
They possess their own multicopy genome, which is maternally transmitted. Mitochondria …

Mammalian oocytes are long-lived cells in the human body. They initiate meiosis already in
the embryonic ovary, arrest meiotically for long periods in dictyate stage, and resume …

Using a semi-quantitative review of published electron micrographs, we have explored the
passage of mitochondria from one generation to the next through the cytoplasm of the …

OBJECTIVE: To evaluate the relationship between mitochondrial gene expression of
oocytes/embryos and their fertilizability in unfertilized oocytes, arrested embryos, and …

Mitochondria (mt) have been reported to be closely related to the maturation of mammalian
oocytes, but their function in oocyte maturation has not been elucidated. In this study, we …

Ovarian aging is characterized by a decline in both the total number and overall quality of
oocytes, the latter of which has been experimentally tied to mitochondrial dysfunction …

Mitochondria are the most prominent organelle in the oocyte. Somatic cells maintain a
healthy population of mitochondria by degrading damaged mitochondria via mitophagy, a …

Mitochondria, fundamental organelles in cell metabolism, and ATP synthesis are
responsible for generating reactive oxygen species (ROS), calcium homeostasis, and cell …