[HTML][HTML] Placental mitochondrial dysfunction with metabolic diseases: Therapeutic approaches

JF Hebert, L Myatt - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 2021 - Elsevier
Both obesity and gestational diabetes mellitus (GDM) lead to poor maternal and fetal
outcomes, including pregnancy complications, fetal growth issues, stillbirth, and …

Placental mitochondria and reactive oxygen species in the physiology and pathophysiology of pregnancy

JJ Fisher, LA Bartho, AV Perkins… - Clinical and …, 2020 - Wiley Online Library
Mitochondria are central to cell function. The placenta forms the interface between maternal
and fetal systems, and placental mitochondria have critical roles in maintaining pregnancy …

Mitochondria in early development: linking the microenvironment, metabolism and the epigenome

AJ Harvey - Reproduction, 2019 - rep.bioscientifica.com
Mitochondria, originally of bacterial origin, are highly dynamic organelles that have evolved
a symbiotic relationship within eukaryotic cells. Mitochondria undergo dynamic, stage …

[HTML][HTML] Aging and the environment affect gamete and embryo potential: can we intervene?

DR Meldrum, RF Casper, A Diez-Juan, C Simon… - Fertility and sterility, 2016 - Elsevier
Optimal maturation of the oocyte depends on its environment and determines embryo
competence, because the embryonic genome is not active until the cleavage stage and new …

Mitochondrial dysfunction in obesity and reproduction

M Das, C Sauceda, NJG Webster - Endocrinology, 2021 - academic.oup.com
Mounting evidence suggests a role for mitochondrial dysfunction in the pathogenesis of
many diseases, including type 2 diabetes, aging, and ovarian failure. Because of the central …