Medroxyprogesterone acetate (MPA) is a first generation progestin that has been in clinical
use for various hormonal conditions in women since the 1960s. Although developed as a …

Sex steroid hormone progesterone is known to have profound effects on the growth and
differentiation of the normal mammary gland and malignant breast epithelial cells. In vitro …

Introduction Medroxyprogesterone acetate (MPA), the major progestin used for oral
contraception and hormone replacement therapy, has been implicated in increased breast …

Background In breast cancer, progesterone receptor (PR) positivity or abundance is
positively associated with survival and treatment response. It was initially believed that PR …

Progesterone receptor (PR) is a master regulator in female reproductive tissues that controls
developmental processes and proliferation and differentiation during the reproductive cycle …

Synthetic progesterone used in contraception drugs (progestins) can promote breast cancer
growth, but the mechanisms involved are unknown. Moreover, it remains unclear whether …

There is emerging interest in understanding the role of progesterone receptors (PRs) in
breast cancer. The aim of this study was to investigate the proliferative effect of progestins …

The ovarian steroid hormone progesterone and its nuclear receptor, the Progesterone
Receptor (PR), play an essential role in the regulation of cell proliferation and differentiation …

Steroid hormones, in particular estrogen and progesterone, play important roles in normal
and neoplastic breast development. Alterations in both estrogen signaling and progesterone …

Progesterone receptor (PR) and its specific ligand play a key role in development and
physiology of mammary gland. The role of PR in initiation and progression of breast …