Matrine (MAR), oxymatrine (OMAR), and sophoridine (SPD) are natural alkaloids with
varying biological activities; matrine was recently used for the treatment of coronavirus …

The formation of co-amorphous by combining low molecular weight compounds with drugs
is a relatively new technology in the pharmaceutical field, which can significantly improve …

There is a great interest to develop co-amorphous drug delivery systems to enhance the
solubility of biopharmaceutics classification system (BCS) class II and IV drugs. However …

Different from previous co-amorphous systems, co-amorphous resveratrol and piperine
(namely RES-PIP CM) showed much lower dissolution in comparison to the original two …

Coamorphous drug delivery systems have shown great potential in improving the solubility
and bioavailability of poorly water-soluble drugs. However, the coamorphous formation …

Co-amorphous supersaturated drug delivery systems are emerging as an alternative
strategy to improve the water solubility of BCS II drugs. Typically, the supersaturation and …

The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has stimulated the search for effective drugs for its …

Co-amorphous and co-crystal systems are attractive crystal-engineering strategies for poorly
soluble drugs. Intermolecular interactions between components play a key role in the …

Tadalafil and repaglinide, categorized as BCS class II drugs, have low oral bioavailabilities
due to their poorly aqueous solubilities and dissolutions. The aim of this study was to …

Developing co-amorphous systems is an attractive strategy to improve the dissolution rate of
poorly water-soluble drugs. Various co-formers have been investigated. However, previous …