Dipeptides as co-formers in co-amorphous systems

W Wu, K Löbmann, J Schnitzkewitz, A Knuhtsen… - European Journal of …, 2019 - Elsevier
Drug-amino acid co-amorphous systems have become increasingly well-investigated
systems to improve dissolution rate of poorly water-soluble drugs. In this study, dipeptides …

Organic acids as co-formers for co-amorphous systems–Influence of variation in molar ratio on the physicochemical properties of the co-amorphous systems

W Wu, H Ueda, K Löbmann, T Rades… - European Journal of …, 2018 - Elsevier
Co-amorphous drug delivery systems are attracting increasing attention in the
pharmaceutical field, due to their promising potential to improve the solubility and …

[HTML][HTML] A small molecule compound berberine as an orally active therapeutic candidate against COVID‐19 and SARS: A computational and mechanistic study

ZZ Wang, K Li, AR Maskey, W Huang… - The FASEB …, 2021 - ncbi.nlm.nih.gov
The novel coronavirus disease, COVID‐19, has grown into a global pandemic and a major
public health threat since its breakout in December 2019. To date, no specific therapeutic …

Drug delivery of amoxicillin molecule as a suggested treatment for covid-19 implementing functionalized mesoporous SBA-15 with aminopropyl groups

HF Alazzawi, IK Salih, TM Albayati - Drug Delivery, 2021 - Taylor & Francis
SARS-CoV-2 is a novel coronavirus that was isolated and identified for the first time in
Wuhan, China in 2019. Nowadays, it is a worldwide danger and the WHO named it a …

[HTML][HTML] Current updates on naturally occurring compounds recognizing SARS-CoV-2 druggable targets

I Romeo, F Mesiti, A Lupia, S Alcaro - Molecules, 2021 - mdpi.com
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been identified in
China as the etiologic agent of the recent COVID-19 pandemic outbreak. Due to its high …

On the role of salt formation and structural similarity of co-formers in co-amorphous drug delivery systems

W Wu, K Löbmann, T Rades, H Grohganz - International journal of …, 2018 - Elsevier
Co-amorphous drug delivery systems based on amino acids as co-formers have shown
promising potential to improve the solubility and bioavailability of poorly water-soluble …

[HTML][HTML] Co-amorphous solid dispersion systems of lacidipine-spironolactone with improved dissolution rate and enhanced physical stability

Z Wang, M Sun, T Liu, Z Gao, Q Ye, X Tan… - Asian Journal of …, 2019 - Elsevier
Co-amorphous solid dispersion (C-ASD) systems have attracted great attention to improve
the solubility of poorly soluble drugs, but the selection of an appropriate stabilizer to stabilize …

Recent advances in enhancement of dissolution and supersaturation of poorly water-soluble drug in amorphous pharmaceutical solids: A review

Q Shi, F Li, S Yeh, SM Moinuddin, J Xin, J Xu… - Aaps Pharmscitech, 2022 - Springer
Amorphization is one of the most effective pharmaceutical approaches to enhance the
dissolution and oral bioavailability of poorly water-soluble drugs. In recent years, amorphous …

Formulation of co-amorphous systems from naproxen and naproxen sodium and in situ monitoring of physicochemical state changes during dissolution testing by …

H Ueda, JP Bøtker, M Edinger, K Löbmann… - International Journal of …, 2020 - Elsevier
Co-amorphous systems comprising low-molecular weight drugs and co-formers constitute
an interesting approach to optimize pharmaceutical performance of drugs with low aqueous …

Amino acids as co-amorphous excipients for tackling the poor aqueous solubility of valsartan

Y Huang, Q Zhang, JR Wang, KL Lin… - Pharmaceutical …, 2017 - Taylor & Francis
Co-amorphization has recently been shown to be a promising approach for stabilizing
amorphous drugs and improving the dissolution rate of poorly water-soluble drugs. In this …