'Poly phenolic phytoceutical loaded nano-bilosomes for enhanced caco-2 cell permeability and SARS-CoV 2 antiviral activity': in-vitro and insilico studies

MY Zakaria, SM Abd El-Halim, BY Beshay, I Zaki… - Drug Delivery, 2023 - Taylor & Francis
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) predisposed to the
emergence of worldwide catastrophe that impels the evolution of safe and effective …

[HTML][HTML] Discovery of anti-SARS-CoV-2 agents from commercially available flavor via docking screening

J Zhang, X Shen, Y Li, Y Yan, Y Wang… - Medicinal Plant …, 2023 - maxapress.com
Flavor and spice are largely consumed in food, cosmetics, and pharmaceutical industries. A
novel coronavirus, recently named the Severe Acute Respiratory Syndrome Coronavirus 2 …

Amorphization strategy affects the stability and supersaturation profile of amorphous drug nanoparticles

WS Cheow, TY Kiew, Y Yang… - Molecular …, 2014 - ACS Publications
Amorphous drug nanoparticles have recently emerged as a promising bioavailability
enhancement strategy of poorly soluble drugs attributed to the high supersaturation …

Gelation elimination and crystallization inhibition by co-amorphous strategy for amorphous curcumin

J Han, Y Wei, L Li, Y Song, Z Pang, S Qian… - Journal of …, 2023 - Elsevier
In the previous study, the development of amorphous curcumin (CUR) aimed to enhance the
solubility/dissolution of CUR by disrupting its crystal lattice, but it unexpectedly showed a …

[HTML][HTML] Opportunities for successful stabilization of poor glass-forming drugs: a stability-based comparison of mesoporous silica versus hot melt extrusion …

F Ditzinger, DJ Price, A Nair, J Becker-Baldus… - Pharmaceutics, 2019 - mdpi.com
Amorphous formulation technologies to improve oral absorption of poorly soluble active
pharmaceutical ingredients (APIs) have become increasingly prevalent. Currently, polymer …

Exploring the formation mechanism of coamorphous andrographolide-oxymatrine based on molecular dynamics and spectroscopy

X Fang, Y Hu, Z Huang, L Han, B Li, S Lu… - Journal of Pharmaceutical …, 2022 - Elsevier
Coamorphous drug delivery systems have shown great potential in improving the solubility
and bioavailability of poorly water-soluble drugs. However, the coamorphous formation …

Co-amorphous Drug Delivery Systems: a Review of Physical Stability, In Vitro and In Vivo Performance

Q Shi, Y Wang, SM Moinuddin, X Feng, F Ahsan - AAPS PharmSciTech, 2022 - Springer
Over the past few decades, co-amorphous solids have been used as a promising approach
for delivering poorly water-soluble drugs. Co-amorphous solids, comprising …

The formation of an amorphous composite between flavonoid compounds: Enhanced solubility in both oil components and aqueous media

H Uchiyama, T Ando, K Kadota, Y Tozuka - Journal of Drug Delivery …, 2021 - Elsevier
In this study, the formation of naringenin (NRG) amorphous composite using coformer
candidates of nine selected flavonoids was investigated. The screening test showed that …

[HTML][HTML] Identification of herbal teas and their compounds eliciting antiviral activity against SARS-CoV-2 in vitro

VTK Le-Trilling, D Mennerich, C Schuler, R Sakson… - BMC biology, 2022 - Springer
Abstract Background The SARS-CoV-2/COVID-19 pandemic has inflicted medical and
socioeconomic havoc, and despite the current availability of vaccines and broad …

Sustainable bioactive salts fully composed of natural products for enhanced pharmaceutical applicability

M Wang, Z Wang, J Zhang, J Zhan, C Wu… - ACS Sustainable …, 2022 - ACS Publications
Phenolic acids are attractive plant-derived bioactive substances owing to their wide range of
pharmaceutical properties for the prevention of various human diseases as well as their …