Modeling brain tumor formation in experimental animals with somatic cell gene transfer has
a long history. In the early experiments naturally occurring retroviruses were used to induce …

Despite impressive improvements in neurosurgical techniques, radiation and chemotherapy
during the past few years, little progress has been made in the treatment of malignant …

Techniques that enable neurobiologists to prepare large, pure populations of specific neural
cell types would be very powerful. The diversity and postmitotic nature of neurons, however …

Using a neural transplantation model which mimics structural and functional properties of
the normal rat brain to a high extent, we have taken a novel approach to study the …

Efficient virus and non-virus vector systems for gene transfer to tumor cells have been
developed and tested in cell culture and in animal experiments. With some of the earliest …

A gene transfer model was developed which allows for the identification of transformation
pathways in the developing nervous system. Transforming genes were introduced into fetal …

PURPOSE Brain tumors were the first human malignancy to be targeted by therapeutic
transfer of nucleic acids into somatic cells, a process also known as gene therapy. Malignant …

Advances in understanding and controlling genes and their expression have set the stage to
alter genetic material to fight or prevent disease with brain tumors being among one of the …

Cancer gene therapy is based on the transfer of genetic material to cancer cells to modify a
normal or abnormal cellular function, or to induce cell death. Modified viruses or stem cells …

Recombinant retrovirus vectors for treatment of malignant brain tumors Page 209 RECOMBINANT
RETROVIRUS VECTORS FOR TREATMENT OF MALIGNANT BRAIN TUMORS Nikolai G …