Abstract Purpose of Review Stem cells respond to local paracrine signals; more recently,
however, systemic hormones have also emerged as key regulators of stem cells. This review …

Only a small number of cells in adult tissues (the stem cells) possess the ability to self-renew
at every cell division, while producing differentiating daughter cells to maintain tissue …

Steroid hormones are known systemic regulators of multiple normal and cancerous tissues;
however, whether or how they impact the fate and function of adult stem cells is unclear. In …

Stem cells depend on intrinsic and local factors to maintain their identity and activity, but they
also sense and respond to changing external conditions. We previously showed that …

Stem cell regulation by local signals is intensely studied, but less is known about the effects
of hormonal signals on stem cells. In Drosophila, the primary steroid twenty …

Highlights•Systemic factors control dietary response of GSCs via acting on the GSC itself,
GSC niche cells, and the adipose tissue surrounding the ovary.•The adipose tissue, a …

Tissue-specific stem cells are tied to the nutritional and physiological environment of adult
organisms. Adipocytes have key endocrine and nutrient-sensing roles and have emerged as …

Stem cells have the unique potential to self‐renew and to supply differentiated cells that
replenish lost cells throughout an organism's lifetime. This unique property makes stem cells …

Much effort is being invested in defining the intrinsic and extrinsic factors that control stem
cell maintenance and proliferation. Recent studies have identified a signaling hierarchy …

Many organs respond to physiological challenges by changing tissue size or composition.
Such changes may originate from tissue-specific stem cells and their supportive …