Tooth development is regulated by epithelial-mesenchymal interactions and their reciprocal
molecular signaling. Bone morphogenetic protein 2 (Bmp2) is essential for tooth formation …

Background Periodontitis is the most extensive chronic inflammatory bone resorption
disease. MiRNAs offer a potential way for potential therapy. Indeed, miR-30a-5p had an …

RNA interference (RNAi) has recently become a powerful tool to silence gene expression in
mammalian cells, but its application in assessing gene function in mammalian developing …

Cell fates are determined by specific transcriptional programs. Here we provide evidence
that the transcriptional coactivator, Mediator 1 (Med1), is essential for the cell fate …

Background: Cementum is a critical mineralized tissue; however, control of its formation
remains undefined. One hypothesis is that enamel matrix proteins/peptides secreted by …

Our previous long noncoding RNA (lncRNA) microarray results showed that lncRNA MEG3
(maternally expressed 3) was significantly downregulated in human dental follicle cells than …

miRNAs are endogenously expressed 18-to 25-nucleotide RNAs that regulate gene
expression through translational repression by binding to a target mRNA. Recently, it has …

Normal cell cycle progression and proliferation of palatal mesenchymal cells are important
for palatal development. As targets of miR-17-92, E2F transcription factors family has been …

The role that noncoding regions of the genome play in the etiology of cleft palate is not well
studied. A novel method of microRNA (miR) inhibition that allows for specific miR …

Although Bmp2 is essential for tooth formation, the role of Bmp2 during enamel formation
remains unknown in vivo. In this study, the role of Bmp2 in regulation of enamel formation …