Lysosome-targeted chemotherapeutics: Anticancer mechanism of n-heterocyclic carbene iridium (iii) complex

J Zhang, J Liu, X Liu, B Liu, S Song, X He, C Che… - Journal of Inorganic …, 2020 - Elsevier
N-heterocyclic carbenes-modified half-sandwich iridium (III) complex [(η 5-C 5 Me 4 C 6 H 4
C 6 H 5) Ir (C^ C) Cl] PF 6 (C1)(where C^ C is a N-heterocyclic carbene ligand) can …

Novel and versatile imine-N-heterocyclic carbene half-sandwich iridium (III) complexes as lysosome-targeted anticancer agents

Y Yang, L Guo, Z Tian, Y Gong, H Zheng… - Inorganic …, 2018 - ACS Publications
We, herein, report the synthesis, characterization, luminescence properties, anticancer, and
antibacterial activities of a family of novel half-sandwich iridium (III) complexes of the general …

[HTML][HTML] Imidazole and Benzimidazole Modified Half-Sandwich IridiumIII N-Heterocyclic Carbene Complexes: Synthesis, Anticancer Application, and Organelle …

X Liu, Y Han, X Ge, Z Liu - Frontiers in Chemistry, 2020 - frontiersin.org
Herein, we report the synthesis, characterization and anticancer activity of a series of half-
sandwich iridiumIII imidazole and benzimidazole N-heterocyclic carbene (NHC) anticancer …

Novel lysosome-targeted cyclometalated Iridium (III) anticancer complexes containing imine-N-heterocyclic carbene ligands: synthesis, spectroscopic properties and …

Y Yang, L Guo, X Ge, Z Tian, Y Gong, H Zheng, Q Du… - Dyes and …, 2019 - Elsevier
A series of luminescent cyclometalated iridium (III) anticancer complexes of the type [Ir (ppy)
2 (CˆN)] PF 6−(where CˆN are imine-N-heterocyclic carbene ligands with various …

Half‐sandwich Iridium(III) Benzimidazole‐Appended Imidazolium‐Based N‐heterocyclic Carbene Complexes and Antitumor Application

Y Han, X Liu, Z Tian, X Ge, J Li, M Gao… - Chemistry–An Asian …, 2018 - Wiley Online Library
A series of half‐sandwich iridium (III) benzimidazole‐appended imidazolium‐based N‐
heterocyclic carbene (NHC) antitumor complexes [(η5‐Cpx) Ir (C^ N) Cl] Cl, where Cpx is …

Lysosome‐targeted potent half‐sandwich iridium (III) α‐diimine antitumor complexes

D Kong, L Guo, M Tian, S Zhang, Z Tian… - Applied …, 2019 - Wiley Online Library
Fifteen organometallic Ir (III) half‐sandwich complexes (1A–5C) having the general formula
[(η5‐Cpx) Ir (N^ N) Cl] PF6 (Cpx= Cp*, tetramethyl (phenyl) cyclopentadienyl (Cpxph) or …

Theranostic lysosomal targeting anticancer and antimetastatic agents: half-sandwich iridium (III) rhodamine complexes

W Ma, X Ge, Z Xu, S Zhang, X He, JJ Li, X Xia… - ACS …, 2019 - ACS Publications
Two rhodamine-modified half-sandwich Ir (III) complexes with the general formula [(Cpx) Ir
(ĈN) Cl] were synthesized and characterized, where Cpx is 1-biphenyl-2, 3, 4, 5 …

Lysosome targeted drugs: rhodamine B modified N^ N-chelating ligands for half-sandwich iridium (III) anticancer complexes

W Ma, Z Tian, S Zhang, X He, JJ Li, X Xia… - Inorganic Chemistry …, 2018 - pubs.rsc.org
We designed and synthesized four rhodamine-modified half-sandwich iridium complexes
([(η5-Cpx) Ir (N^ N) Cl] PF6). The fluorescence properties of the complexes were studied …

Lysosome-targeted iridium (III) compounds with pyridine-triphenylamine Schiff base ligands: Syntheses, antitumor applications and mechanisms

S Chen, X Liu, X Ge, Q Wang, Y Xie, Y Hao… - Inorganic Chemistry …, 2020 - pubs.rsc.org
Six N-phenylcarbazole/triphenylamine modified half-sandwiched iridium (III) Schiff base
compounds ([(η5-Cpx) Ir (N^ N) Cl] PF6) were synthesised and characterised in this study …

Novel half-sandwich iridium OˆC (carbene)-Complexes: In vitro and in vivo tumor growth suppression and pro-apoptosis via ROS-mediated cross-talk between …

Z Xu, Y Zhang, S Zhang, X Jia, G Zhong, Y Yang, Q Du… - Cancer letters, 2019 - Elsevier
Herein we present half-sandwich Ir III complexes [(η 5-Cp xbiph) Ir (OˆC) Cl] containing OˆC
(NHC)-chelating ligand as anticancer and antimetastasis agents. All the complexes …