Rationale: Chronic obstructive pulmonary disease (COPD) can develop not only through a
lung function trajectory dominated by an accelerated decline of FEV1 from normal maximally …

Background Chronic obstructive pulmonary disease (COPD) is thought to result from an
accelerated decline in forced expiratory volume in 1 second (FEV1) over time. Yet it is …

Rationale: Chronic obstructive pulmonary disease (COPD) is thought to result in rapid and
progressive loss of lung function usually expressed as mean values for whole cohorts …

Rationale: Acute exacerbations of chronic obstructive pulmonary disease (COPD) increase
the risk of death and drive healthcare costs, but whether they accelerate loss of lung function …

Accelerated lung function decline has been associated with increased risk of cardiovascular
disease (CVD) in a general population, but little is known about this association in chronic …

Rationale: Although the rate of annual decline in FEV1 is one of the most important outcome
measures in chronic obstructive pulmonary disease (COPD), little is known about …

Rationale: Spirometry is essential for diagnosis and assessment of prognosis in patients
with chronic obstructive pulmonary disease (COPD). Objectives: To identify FEV1 …

Purpose To quantify the relationship between severity of chronic obstructive pulmonary
disease (COPD) as expressed by Global Initiative for Chronic Obstructive Lung Disease …

Background Estimates for lung function decline in chronic obstructive pulmonary disease
(COPD) have differed by study setting and have not been described in a UK primary care …

COPD is complex and there are multiple determinants of poor health, so most studies of
Chronic Obstructive Pulmonary Disease (COPD) now include health status, or health related …