The PI3K-dependent activation of AKT results in the inhibition of GSK3β in most signaling
pathways. These kinases regulate multiple neuronal processes including the control of …

Glycogen synthase kinase-3β (GSK3β) is recognized as one of major kinases to
phosphorylate tau in Alzheimer's disease (AD), thus lots of AD drug discoveries target …

Extensive evidence implicates GluN2B-containing NMDA receptors (GluN2B-NMDARs) in
excitotoxic-insult-induced neurodegeneration and amyloid β (Aβ)-induced synaptic …

There are two different types of Alzheimers' disease, familiar Alzheimers' disease (FAD) and
Sporadic Alzheimers' disease (SAD), and the origin of the disease could be different in both …

Highly phosphorylated τ protein is the main component of paired helical filaments (PHF),
which comprise the neurofibrillary tangles (NFT) in some neurons of patients with Alzheimer …

Glycogen synthase kinase-3 (GSK-3) is a serine/threonine kinase originally identified as a
regulator of glycogen metabolism but it also plays a pivotal role in numerous cellular …

Accumulating evidence suggests that glycogen synthase kinase 3 (GSK-3) is a
multifunctional kinase implicated in neuronal development, mood stabilization, and …

The hippocampus and entorhinal cortex (EC) accumulate amyloid beta peptides (Aβ) that
promote neuropathology in Alzheimer's disease, but the early effects of Aβ on excitatory …

Currently, treatment with the relatively low-affinity NMDA receptor antagonist memantine
provides limited benefit in Alzheimer's disease (AD). One probable dose-limiting factor in the …

J. Neurochem.(2011) 10.1111/j. 1471‐4159.2011. 07532. x Abstract Alzheimer's disease
(AD) is a neurodegenerative disorder leading to a progressive loss of cognitive function and …