Glycogen synthase kinase-3 (GSK-3) is a serine/threonine kinase originally identified as a
regulator of glycogen metabolism but it also plays a pivotal role in numerous cellular …

Abstract Glycogen synthase kinase (GSK)-3β is a multifunctional protein that has been
implicated in the pathological characteristics of Alzheimer's disease (AD), including the …

The toxicity of amyloid β (Aβ) is highly associated with Alzheimer's disease (AD), which has
a high incidence in elderly people worldwide. While the current treatment for moderate and …

J. Neurochem.(2011) 10.1111/j. 1471‐4159.2011. 07532. x Abstract Alzheimer's disease
(AD) is a neurodegenerative disorder leading to a progressive loss of cognitive function and …

Oscillatory activity in the entorhinal cortex has been associated with several cognitive
functions. Accordingly, Alzheimer Disease-associated cognitive decline has been related to …

The mechanisms by which β-amyloid (Aβ), a peptide fragment believed to contribute to
Alzheimer's disease, leads to synaptic deficits are not known. Here we find that elevated …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that leads to
debilitating cognitive deficits. Recent evidence demonstrates that glutamate receptors are …

Amyloid beta (Aβ)-mediated synapse dysfunction is an early event in Alzheimer's disease
(AD) pathogenesis and previous studies suggest that NMDA receptor (NMDAR) …

Onset and progression of Alzheimer's disease (AD) pathophysiology differs between brain
regions. The neocortex, for example, is a brain region that is affected very early during AD …

Abstract Glycogen synthase kinase3 (GSK3) is emerging as a prominent drug target in the
CNS. The most exciting of the possibilities of GSK3 lies within the treatment of Alzheimer's …