In religious philosophy, the concept of karma represents the effect of one's past and present
actions on one's future. Macrophages are highly plastic cells with myriad roles in health and …

Adoptive cell therapy with genetically modified T cells has generated exciting outcomes in
hematologic malignancies, but its application to solid tumors has proven challenging. This …

Anticancer immunotherapies are therapeutics aimed at eliciting immune responses against
tumor cells. Immunotherapies based on adoptive transfer of engineered immune cells have …

Recent understanding of the role and contribution of immune cells in disease onset and
progression has pioneered the field of immunotherapies. Use of genetic engineering to …

Chimeric antigen receptor (CAR) T cell immunotherapy has demonstrated profound results
in hematologic malignancies but clinical efficacy in the solid tumor setting has not been …

Macrophages get a CAR | Nature Reviews Cancer Skip to main content Thank you for visiting
nature.com. You are using a browser version with limited support for CSS. To obtain the best …

Background: Cells of the immune system can inhibit tumor growth and progression;
however, immune cells can also promote tumor cell growth, survival, and angiogenesis as a …

Macrophages are multi-functional innate immune cells that occupy normal or pathologic
tissues, including cancer tissues. The importance of macrophage ontogeny and the …

Chimeric antigen receptor (CAR) T cell therapy has shown promise in hematologic
malignancies, but its application to solid tumors has been challenging,,–. Given the unique …

Cellular immunotherapies represent a promising approach for the treatment of cancer.
Engineered adoptive cell therapies redirect and augment a leukocyte's inherent ability to …