Immunotherapy has improved cancer treatment based on investigations of tumor immune
escape. Manipulation of the immune system stimulates antitumor immune responses and …

Macrophages, as one of the most abundant tumor-infiltrating cells, play an important role in
tumor development and metastasis. The frequency and polarization of tumor-associated …

Chimeric Antigen Receptor (CAR) technology has revolutionized cellular immunotherapy,
particularly with the success of CAR-T cells in treating hematologic malignancies. However …

Preliminary results and emerging data have shown that lipid droplet high (LDhi)
immunosuppressive cells accumulate in tumour tissues. By tracking and phenotypic profiling …

Macrophages are essential innate immune cells found throughout the body that have
protective and pathogenic functions in many diseases. When activated, macrophages can …

Macrophages and neutrophils are the main components of the innate immune system and
play important roles in promoting angiogenesis, extracellular matrix remodeling, cancer cell …

The Chimeric antigen receptor (CAR)-T cell therapy has made inroads in treating
hematological malignancies. Nonetheless, there are still multiple hurdles in CAR-T cell …

Macrophages play critical roles in tumor progression. In the tumor microenvironment,
macrophages display highly diverse phenotypes and may perform antitumorigenic or …

Macrophages (Mϕs) play an essential role in maintaining body homeostasis. They perform
dual functions produced by different subtypes. Mϕs not only fight against pathogens and …

Macrophages constitute a dominant fraction of the population of immune cells that infiltrate
developing tumors. Recruited by tumor-derived signals, tumor-infiltrating macrophages are …