Simple Summary Macrophages are the “big eaters” of the immune system who are in charge
of engulfing undesirable substances. Macrophages are vital for the human body as they are …

The tumor microenvironment is overwhelmingly dictated by macrophages, intimately
affiliated with tumors, exercising pivotal roles in multiple processes, including angiogenesis …

As far back as 1882, Ilya (Elie) Metchnikoff was the first to discover macrophages (MΦ) and
their important role in host defense [1]. Now, almost 140 years later, MΦ are known as …

Tumor-associated macrophages (TAMs) play a central role in tumor progression, metastasis,
and recurrence after treatment. Macrophage plasticity and diversity allow their classification …

Chimeric antigen receptor (CAR) T cell treatment has provided notable results in
hematological tumors. Unfortunately, this evidence has not been translated into improved …

Therapeutic approaches that engage immune cells to treat cancer are becoming
increasingly utilized in the clinics and demonstrated durable clinical benefit in several solid …

As fundamental immune cells in innate and adaptive immunity, macrophages engage in a
double-edged relationship with cancer. Dissecting the character of macrophages in cancer …

Tumors are composed of heterogeneous cell populations recruited by cancer cells to
promote growth and metastasis. Among cells comprising the tumor stroma, myeloid-derived …

Macrophages are the main component of the tumor microenvironment, which are
differentiated from monocytes in the blood and play an important role in cancer …

Chimeric antigen receptor (CAR)-T cell therapy has been shown to be an effective treatment
for hematological tumors, but the treatment of solid tumors still lacks effectiveness. In the …