Although narcotic analgesics and formulations containing opioids are the most commonly
used agents for the treatment of moderate to severe pain, the use of exogenous drug …

Despite recent advances in the understanding of mechanisms underlying persistent pain
development and maintenance, the therapeutic management of chronic pain remains a …

Cell transplantation is a potentially powerful approach for the alleviation of chronic pain. The
strategy of cell transplantation for the treatment of pain is focused on cell-based analgesia …

The management of chronic pain, particularly neuropathic pain, still has significant unmet
needs. In addition to inadequate symptomatic relief, there are concerns about adverse …

The transplantation of cells that secrete neuroactive substances with analgesic properties
into the CNS is a novel method that challenges current approaches in treating chronic pain …

Accumulating clinical evidence of functional neurorestoration for nervous system damages
or diseases has been reported using a variety of therapies, especially cell-based therapies …

Chronic pain represents a clinical problem of enormous impact. Understanding of the
anatomy, pharmacology, and physiology of pain has resulted in the identification of new …

This chapter reviews the cell transplantation strategies that have been explored as potential
options in the treatment of pain and traumatic brain injury (TBI). As the goals of these two …

This invention provides a method of alleviating chronic pain in humans. Viable, implantable
cells are selected which release neuroactive substances that reduce chronic pain. The cells …

Abstract Development of novel therapies is required to transform care for chronic and
refractory pain due to degenerative and neuropathic conditions. Mesenchymal stem cell …