It is thought that immunity depends on naïve CD4 T cells that proliferate in response to
microbial antigens,,,, differentiate into memory cells that produce anti-microbial …

Memory CD8 T cells, generated by natural pathogen exposure or intentional vaccination,
protect the host against specific viral infections. It has long been proposed that the number of …

A hallmark of adaptive immunity is the generation of memory T cells that confer long-lived,
antigen-specific protection against repeat challenges by pathogens,,,,. Understanding the …

The differentiation of human memory CD8 T cells is not well understood. Here we address
this issue using the live yellow fever virus (YFV) vaccine, which induces long-term immunity …

Memory CD8 T cells that circulate in the blood and are present in lymphoid organs are an
essential component of long-lived T cell immunity. These memory CD8 T cells remain …

The origins of memory T cells Skip to main content Thank you for visiting nature.com. You are
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Immunological memory is the ability of the immune system to respond with enhanced vigour
to pathogens that have been encountered in the past. Following infection or immunization …

MEMORY is a hallmark of the immune system and ever since its recognition there has been
considerable interest in understanding how immunity is maintained1–5. The current model …

A long-standing paradox in cellular immunology concerns the conditional requirement for
CD4+ T-helper (TH) cells in the priming of cytotoxic CD8+ T lymphocyte (CTL) responses in …

Immunization in the absence of CD4+ T cell help results in defective CD8+ T cell memory,
deficient recall responses and diminished protective immunity. Here we investigated at what …