Imaging biomarkers in Parkinson's disease

DJ Brooks, N Pavese - Progress in neurobiology, 2011 - Elsevier
Parkinson's disease (PD) is characterized by a progressive loss of nigrostriatal
dopaminergic neurons associated with intracellular Lewy inclusion bodies. The result is …

PET and SPECT functional imaging studies in Parkinsonian syndromes: from the lesion to its consequences

S Thobois, M Jahanshahi, S Pinto, R Frackowiak… - Neuroimage, 2004 - Elsevier
Functional imaging techniques provide major insights into understanding the
pathophysiology, progression, complications, and differential diagnosis of Parkinson's …

What a neurologist should know about PET and SPECT functional imaging for parkinsonism: a practical perspective

S Thobois, S Prange, C Scheiber… - Parkinsonism & related …, 2019 - Elsevier
The diagnosis of a parkinsonian syndrome based on clinical criteria remains sometimes
difficult, especially at disease onset. Brain or heart molecular imaging techniques (SPECT or …

[HTML][HTML] Positron emission tomography neuroimaging in Parkinson's disease

C Loane, M Politis - American journal of translational research, 2011 - ncbi.nlm.nih.gov
Positron emission tomography (PET) is a nuclear imaging technique, which allows in vivo
estimations of important physiological parameters such as, glucose metabolism and …

Parkinson's disease: in vivo assessment of disease progression using positron emission tomography

WL Au, JR Adams, AR Troiano, AJ Stoessl - Molecular brain research, 2005 - Elsevier
Over the past two decades, positron emission tomography (PET) has provided valuable
insights into the mechanisms of nigrostriatal degeneration in Parkinson's disease (PD) …

A systematic review of lessons learned from PET molecular imaging research in atypical parkinsonism

F Niccolini, M Politis - European journal of nuclear medicine and …, 2016 - Springer
Purpose To systematically review the previous studies and current status of positron
emission tomography (PET) molecular imaging research in atypical parkinsonism. Methods …

Structural and functional imaging in parkinsonian syndromes

SM Broski, CH Hunt, GB Johnson, RF Morreale… - Radiographics, 2014 - pubs.rsna.org
Movement disorders with parkinsonian features are common, and in recent years imaging
has assumed a greater role in diagnosis and management. Thus, it is important that …

The role of neuroimaging in Parkinson's disease

NSR Bidesi, I Vang Andersen… - Journal of …, 2021 - Wiley Online Library
Parkinson's disease (PD) is a neurodegenerative disorder that affects millions of people
worldwide. Two hallmarks of PD are the accumulation of alpha‐synuclein and the loss of …

Clinical, dopaminergic, and metabolic correlations in Parkinson disease: a dual-tracer PET study

FT Liu, JJ Ge, JJ Wu, P Wu, Y Ma, CT Zuo… - Clinical nuclear …, 2018 - journals.lww.com
Purpose Neuroimaging indicators of Parkinson disease have been developed and applied
in clinical practices. Dopaminergic imaging reflects nigrostriatal dopaminergic dysfunction …

Recent advances in PET imaging for evaluation of Parkinson's disease

C Sioka, A Fotopoulos, AP Kyritsis - European journal of nuclear medicine …, 2010 - Springer
Parkinson's disease (PD) consists of loss of pigmented dopamine-secreting neurons in the
pars compacta of the midbrain substantia nigra. These neurons project to the striatum …