Nitric oxide pathways in neurovascular coupling under normal and stress conditions in the brain: strategies to rescue aberrant coupling and improve cerebral blood …
CF Lourenço, J Laranjinha - Frontiers in physiology, 2021 - frontiersin.org
The brain has impressive energy requirements and paradoxically, very limited energy
reserves, implying its huge dependency on continuous blood supply. Aditionally, cerebral …
reserves, implying its huge dependency on continuous blood supply. Aditionally, cerebral …
Neurovascular and neurometabolic derailment in aging and Alzheimer's disease
CF Lourenço, A Ledo, C Dias, RM Barbosa… - Frontiers in aging …, 2015 - frontiersin.org
The functional and structural integrity of the brain requires local adjustment of blood flow and
regulated delivery of metabolic substrates to meet the metabolic demands imposed by …
regulated delivery of metabolic substrates to meet the metabolic demands imposed by …
Neurovascular-neuroenergetic coupling axis in the brain: master regulation by nitric oxide and consequences in aging and neurodegeneration
CF Lourenço, A Ledo, RM Barbosa… - Free Radical Biology and …, 2017 - Elsevier
The strict energetic demands of the brain require that nutrient supply and usage be fine-
tuned in accordance with the specific temporal and spatial patterns of ever-changing levels …
tuned in accordance with the specific temporal and spatial patterns of ever-changing levels …
Targeting nitrosative stress for neurovascular protection: new implications in brain diseases
Nitric oxide/peroxynitrite signaling is associated with manifold neurovascular pathogenic
cascades that lead to neurodegenerative diseases, including ischemic stroke, Alzheimer's …
cascades that lead to neurodegenerative diseases, including ischemic stroke, Alzheimer's …
Nitric oxide and cerebrovascular regulation
SN Tabatabaei, H Girouard - Vitamins & hormones, 2014 - Elsevier
The cerebrovascular regulation involves highly complex mechanisms to assure that the
brain is perfused at all times. These mechanisms depend on all components of the …
brain is perfused at all times. These mechanisms depend on all components of the …
The role of nitrite in neurovascular coupling
B Piknova, A Kocharyan, AN Schechter, AC Silva - Brain research, 2011 - Elsevier
Nitric oxide (NO), a potent vasodilator and nontraditional neurotransmitter, is an important
mediator of the changes in cerebral blood flow (CBF) associated with increased neuronal …
mediator of the changes in cerebral blood flow (CBF) associated with increased neuronal …
Nitric oxide is fundamental to neurovascular coupling in humans
RL Hoiland, HG Caldwell, CA Howe… - The Journal of …, 2020 - Wiley Online Library
Key points Preclinical models have demonstrated that nitric oxide is a key component of
neurovascular coupling; this has yet to be translated to humans. We conducted two separate …
neurovascular coupling; this has yet to be translated to humans. We conducted two separate …
Nitric oxide signaling in the brain: a new target for inhaled nitric oxide?
C Charriaut‐Marlangue, P Bonnin, H Pham… - Annals of …, 2013 - Wiley Online Library
Nitric oxide (NO) is a powerful vasodilator, involved in both physiological functions and
pathophysiological alterations of various regulatory processes, for example, the …
pathophysiological alterations of various regulatory processes, for example, the …
The role of nitric oxide in neurovascular coupling
Nitric oxide (NO) is a neurotransmitter known to act as a potent cerebral vasodilator. Its role
in neurovascular coupling (NVC) is discussed controversially and one of the main …
in neurovascular coupling (NVC) is discussed controversially and one of the main …
Neurovascular coupling in hippocampus is mediated via diffusion by neuronal-derived nitric oxide
CF Lourenço, RM Santos, RM Barbosa… - Free Radical Biology …, 2014 - Elsevier
The coupling between neuronal activity and cerebral blood flow (CBF) is essential for
normal brain function. The mechanisms behind this neurovascular coupling process remain …
normal brain function. The mechanisms behind this neurovascular coupling process remain …
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