The brain has impressive energy requirements and paradoxically, very limited energy
reserves, implying its huge dependency on continuous blood supply. Aditionally, cerebral …

The functional and structural integrity of the brain requires local adjustment of blood flow and
regulated delivery of metabolic substrates to meet the metabolic demands imposed by …

The strict energetic demands of the brain require that nutrient supply and usage be fine-
tuned in accordance with the specific temporal and spatial patterns of ever-changing levels …

Nitric oxide/peroxynitrite signaling is associated with manifold neurovascular pathogenic
cascades that lead to neurodegenerative diseases, including ischemic stroke, Alzheimer's …

The cerebrovascular regulation involves highly complex mechanisms to assure that the
brain is perfused at all times. These mechanisms depend on all components of the …

Nitric oxide (NO), a potent vasodilator and nontraditional neurotransmitter, is an important
mediator of the changes in cerebral blood flow (CBF) associated with increased neuronal …

Key points Preclinical models have demonstrated that nitric oxide is a key component of
neurovascular coupling; this has yet to be translated to humans. We conducted two separate …

Nitric oxide (NO) is a powerful vasodilator, involved in both physiological functions and
pathophysiological alterations of various regulatory processes, for example, the …

Nitric oxide (NO) is a neurotransmitter known to act as a potent cerebral vasodilator. Its role
in neurovascular coupling (NVC) is discussed controversially and one of the main …

The coupling between neuronal activity and cerebral blood flow (CBF) is essential for
normal brain function. The mechanisms behind this neurovascular coupling process remain …