Although a good deal is known about the pathophysiology of Parkinson's disease and
information is emerging about its cause, there are no pharmacological treatments shown to …

We are testing the hypothesis that exercise is neuroprotective in animal models of the
dopamine (DA) deficiency in Parkinson's disease. Our studies include mice or rats provided …

Parkinson's disease (PD) is manifested by progressive motor, autonomic, and cognitive
disturbances. Dopamine (DA) synthesizing neurons in the substantia nigra (SN) degenerate …

For many years, exercise was not a recommended rehabilitation strategy for persons with a
diagnosis of idiopathic Parkinson's disease (PD). Since it was believed that exercise had no …

Early after the turn of the century, much excitement was generated by the reports of Tillerson
et al.[1, 2] that exercise appeared to protect against neuronal degeneration in rodent models …

Disease-modifying treatments remain an unmet medical need in Parkinson's disease (PD).
Such treatments can be operationally defined as interventions that slow down the clinical …

Epidemiological and clinical studies have suggested that exercise is beneficial for patients
with Parkinson's disease (PD). Through research in normal (noninjured) animals …

Animal studies have been instrumental in providing evidence for exercise-induced
neuroplasticity of corticostriatal circuits that are profoundly affected in Parkinson's disease …

There is clinical evidence that the symptoms of Parkinson's disease can be ameliorated by
physical exercise, and we have been using animal models to explore the hypothesis that …

For decades, the concept of “disease-modifying” treatment has been used profusely in
several neurodegenerative diseases including Parkinson's disease (PD). This concept has …