Background The availability of genome sequences for many organisms enabled the
reconstruction of several genome-scale metabolic network models. Currently, significant …

Genome-scale metabolic networks have been reconstructed for several organisms. These
metabolic networks provide detailed information about the metabolism inside the cells …

The integration of various types of genomic data into predictive models of biological
networks is one of the main challenges currently faced by computational biology. Constraint …

Background Genome-scale metabolic reconstructions have been recognised as a valuable
tool for a variety of applications ranging from metabolic engineering to evolutionary studies …

Background Constraint-based analysis of genome-scale metabolic models has become a
key methodology to gain insights into functions, capabilities, and properties of cellular …

Systemic approaches to the study of a biological cell or tissue rely increasingly on the use of
context-specific metabolic network models. The reconstruction of such a model from high …

Genome-scale metabolic reconstructions have proven to be valuable resources in
enhancing our understanding of metabolic networks as they encapsulate all known …

Background A central problem in computational metabolic modelling is how to find
biochemically plausible pathways between metabolites in a metabolic network. Two …

Motivation: Information from fully sequenced genomes makes it possible to reconstruct strain-
specific global metabolic network for structural and functional studies. These networks are …

In the last decade, reconstruction and applications of genome-scale metabolic models have
greatly influenced the field of systems biology by providing a platform on which high …