Bioprocessing strategies to improve heterologous protein production in filamentous fungal fermentations

L Wang, D Ridgway, T Gu, M Moo-Young - Biotechnology advances, 2005 - Elsevier
Filamentous fungi have long been used for the production of metabolites and enzymes. With
developments in genetic engineering and molecular biology, filamentous fungi have also …

Increased Heterologous Protein Production in Aspergillusniger Fermentation through Extracellular Proteases Inhibition by Pelleted Growth

J Xu, L Wang, D Ridgway, T Gu… - Biotechnology …, 2000 - Wiley Online Library
The dependence of filamentous fungal protease secretion on morphology was investigated
by employing the recombinant Aspergillus niger strain AB4. 1 [pgpdAGLAGFP] which …

[HTML][HTML] Heterologous protein production in filamentous fungi

D Liu, S Garrigues, RP de Vries - Applied microbiology and biotechnology, 2023 - Springer
Filamentous fungi are able to produce a wide range of valuable proteins and enzymes for
many industrial applications. Recent advances in fungal genomics and experimental …

Approaches for refining heterologous protein production in filamentous fungi

R Sharma, M Katoch, PS Srivastava… - World Journal of …, 2009 - Springer
Fungi combine the advantages of a microbial system such as a simple fermentability with the
capability of secreting proteins that are modified according to a general eukaryotic scheme …

Heterologous gene expression in filamentous fungi

X Su, G Schmitz, M Zhang, RI Mackie… - Advances in applied …, 2012 - Elsevier
Filamentous fungi are critical to production of many commercial enzymes and organic
compounds. Fungal-based systems have several advantages over bacterial-based systems …

Production of recombinant proteins by filamentous fungi

OP Ward - Biotechnology advances, 2012 - Elsevier
The initial focus of recombinant protein production by filamentous fungi related to exploiting
the extraordinary extracellular enzyme synthesis and secretion machinery of industrial …

[HTML][HTML] Fungal cell factories for efficient and sustainable production of proteins and peptides

M Lübeck, PS Lübeck - Microorganisms, 2022 - mdpi.com
Filamentous fungi are a large and diverse taxonomically group of microorganisms found in
all habitats worldwide. They grow as a network of cells called hyphae. Since filamentous …

Strategies for improving heterologous protein production from filamentous fungi

DB Archer, DJ Jeenes, DA Mackenzie - Antonie Van Leeuwenhoek, 1994 - Springer
Despite the naturally high capacity for protein secretion by many species of filamentous
fungi, secteted yields of many heterologous proteins have been comparatively low. The …

Heterologous protein expression in filamentous fungi

KMH Nevalainen, VSJ Te'o, PL Bergquist - Trends in biotechnology, 2005 - cell.com
Filamentous fungi are commonly used in the fermentation industry for the large-scale
production of proteins–mainly industrial enzymes. Recent advances in fungal genomics and …

Disruption of ten protease genes in the filamentous fungus Aspergillus oryzae highly improves production of heterologous proteins

J Yoon, J Maruyama, K Kitamoto - Applied microbiology and biotechnology, 2011 - Springer
Proteolytic degradation by secreted proteases into the culture medium is one of the
significant problems to be solved in heterologous protein production by filamentous fungi …