Enhanced Vaccine Immunogenicity Enabled by Targeted Cytosolic Delivery of Tumor Antigens into Dendritic Cells

NL Truex, A Rondon, SL Rössler, CC Hanna… - ACS Central …, 2023 - ACS Publications
Molecular vaccines comprising antigen peptides and inflammatory cues make up a class of
therapeutics that promote immunity against cancer and pathogenic diseases but often …

Strategy for Identifying Dendritic Cell-Processed CD4+ T Cell Epitopes from the HIV Gag p24 Protein

L Bozzacco, H Yu, J Dengjel, C Trumpfheller… - PloS one, 2012 - journals.plos.org
Mass Spectrometry (MS) is becoming a preferred method to identify class I and class II
peptides presented on major histocompability complexes (MHC) on antigen presenting cells …

Stepwise targeting and tandem responsive peptide nanoparticles enhance immunotherapy through prolonged drug retention

J Cao, Z Gong, X Liu, F Meng, X Sun, X Yuan… - ACS Materials …, 2023 - ACS Publications
Cancer treatments that combine chemotherapy with immunotherapy are becoming
increasingly effective, but chemotherapy is generally considered to have …

A toll-like receptor-activating, self-adjuvant glycan nanocarrier

D Xie, Y Niu, R Mu, S Campos de Souza, X Yin… - Frontiers in …, 2022 - frontiersin.org
The global pandemic of COVID-19 highlights the importance of vaccination, which remains
the most efficient measure against many diseases. Despite the progress in vaccine design …

Protection by dendritic cells-based HIV synthetic peptide cocktail vaccine: preclinical studies in the SHIV-rhesus model

PN Nehete, BP Nehete, P Manuri, L Hill, JL Palmer… - Vaccine, 2005 - Elsevier
Vaccine development efforts against HIV-1 have been hindered because of the high
mutation rate of the virus, and limitations for direct testing of HIV antigens in animal models …

Delivering HIV Gagp24 to DCIR Induces Strong Antibody Responses In Vivo

AL Flamar, V Contreras, S Zurawski, M Montes… - PLoS …, 2015 - journals.plos.org
Targeting dendritic cell-specific endocytic receptors using monoclonal antibodies fused to
desired antigens is an approach widely used in vaccine development to enhance the poor …

Role of linker length and antigen density in nanoparticle peptide vaccine

CH Kapadia, S Tian, JL Perry, JC Luft… - ACS omega, 2019 - ACS Publications
Multiple studies have been published emphasizing the significant role of nanoparticle (NP)
carriers in antigenic peptide-based subunit vaccines for the induction of potent humoral and …

Dendritic cell targeting peptide-based nanovaccines for enhanced cancer immunotherapy

Y Liu, L Yao, W Cao, Y Liu, W Zhai, Y Wu… - ACS Applied Bio …, 2019 - ACS Publications
Immunotherapy emerges as an effective avenue for tumor elimination and has many
advantages compared with traditional surgery, radiotherapy, and chemotherapy. Tumor …

Novel Cell-Penetrating Peptide-Based Vaccine Induces Robust CD4+ and CD8+ T Cell–Mediated Antitumor Immunity

M Derouazi, W Di Berardino-Besson, E Belnoue… - Cancer research, 2015 - AACR
Vaccines that can coordinately induce multi-epitope T cell–mediated immunity, T helper
functions, and immunologic memory may offer effective tools for cancer immunotherapy …

[HTML][HTML] A comparison study of iTEP nanoparticle-based CTL vaccine carriers revealed a surprise relationship between the stability and efficiency of the carriers

S Dong, T Xu, P Zhao, KN Parent, M Chen - Theranostics, 2016 - ncbi.nlm.nih.gov
Vaccine carriers have been shown to enhance cytotoxic T lymphocyte (CTL) epitope peptide
vaccines by addressing intrinsic limitations of the vaccines. We have previously developed …