Enhanced Vaccine Immunogenicity Enabled by Targeted Cytosolic Delivery of Tumor Antigens into Dendritic Cells
Molecular vaccines comprising antigen peptides and inflammatory cues make up a class of
therapeutics that promote immunity against cancer and pathogenic diseases but often …
therapeutics that promote immunity against cancer and pathogenic diseases but often …
Strategy for Identifying Dendritic Cell-Processed CD4+ T Cell Epitopes from the HIV Gag p24 Protein
L Bozzacco, H Yu, J Dengjel, C Trumpfheller… - PloS one, 2012 - journals.plos.org
Mass Spectrometry (MS) is becoming a preferred method to identify class I and class II
peptides presented on major histocompability complexes (MHC) on antigen presenting cells …
peptides presented on major histocompability complexes (MHC) on antigen presenting cells …
Stepwise targeting and tandem responsive peptide nanoparticles enhance immunotherapy through prolonged drug retention
J Cao, Z Gong, X Liu, F Meng, X Sun, X Yuan… - ACS Materials …, 2023 - ACS Publications
Cancer treatments that combine chemotherapy with immunotherapy are becoming
increasingly effective, but chemotherapy is generally considered to have …
increasingly effective, but chemotherapy is generally considered to have …
A toll-like receptor-activating, self-adjuvant glycan nanocarrier
D Xie, Y Niu, R Mu, S Campos de Souza, X Yin… - Frontiers in …, 2022 - frontiersin.org
The global pandemic of COVID-19 highlights the importance of vaccination, which remains
the most efficient measure against many diseases. Despite the progress in vaccine design …
the most efficient measure against many diseases. Despite the progress in vaccine design …
Protection by dendritic cells-based HIV synthetic peptide cocktail vaccine: preclinical studies in the SHIV-rhesus model
PN Nehete, BP Nehete, P Manuri, L Hill, JL Palmer… - Vaccine, 2005 - Elsevier
Vaccine development efforts against HIV-1 have been hindered because of the high
mutation rate of the virus, and limitations for direct testing of HIV antigens in animal models …
mutation rate of the virus, and limitations for direct testing of HIV antigens in animal models …
Delivering HIV Gagp24 to DCIR Induces Strong Antibody Responses In Vivo
AL Flamar, V Contreras, S Zurawski, M Montes… - PLoS …, 2015 - journals.plos.org
Targeting dendritic cell-specific endocytic receptors using monoclonal antibodies fused to
desired antigens is an approach widely used in vaccine development to enhance the poor …
desired antigens is an approach widely used in vaccine development to enhance the poor …
Role of linker length and antigen density in nanoparticle peptide vaccine
Multiple studies have been published emphasizing the significant role of nanoparticle (NP)
carriers in antigenic peptide-based subunit vaccines for the induction of potent humoral and …
carriers in antigenic peptide-based subunit vaccines for the induction of potent humoral and …
Dendritic cell targeting peptide-based nanovaccines for enhanced cancer immunotherapy
Y Liu, L Yao, W Cao, Y Liu, W Zhai, Y Wu… - ACS Applied Bio …, 2019 - ACS Publications
Immunotherapy emerges as an effective avenue for tumor elimination and has many
advantages compared with traditional surgery, radiotherapy, and chemotherapy. Tumor …
advantages compared with traditional surgery, radiotherapy, and chemotherapy. Tumor …
Novel Cell-Penetrating Peptide-Based Vaccine Induces Robust CD4+ and CD8+ T Cell–Mediated Antitumor Immunity
M Derouazi, W Di Berardino-Besson, E Belnoue… - Cancer research, 2015 - AACR
Vaccines that can coordinately induce multi-epitope T cell–mediated immunity, T helper
functions, and immunologic memory may offer effective tools for cancer immunotherapy …
functions, and immunologic memory may offer effective tools for cancer immunotherapy …
[HTML][HTML] A comparison study of iTEP nanoparticle-based CTL vaccine carriers revealed a surprise relationship between the stability and efficiency of the carriers
Vaccine carriers have been shown to enhance cytotoxic T lymphocyte (CTL) epitope peptide
vaccines by addressing intrinsic limitations of the vaccines. We have previously developed …
vaccines by addressing intrinsic limitations of the vaccines. We have previously developed …