A genome-wide mQTL analysis in human adipose tissue identifies genetic variants associated with DNA methylation, gene expression and metabolic traits
P Volkov, AH Olsson, L Gillberg, SW Jørgensen… - PloS one, 2016 - journals.plos.org
Little is known about the extent to which interactions between genetics and epigenetics may
affect the risk of complex metabolic diseases and/or their intermediary phenotypes. We …
affect the risk of complex metabolic diseases and/or their intermediary phenotypes. We …
The presence of methylation quantitative trait loci indicates a direct genetic influence on the level of DNA methylation in adipose tissue
Genetic variants that associate with DNA methylation at CpG sites (methylation quantitative
trait loci, meQTLs) offer a potential biological mechanism of action for disease associated …
trait loci, meQTLs) offer a potential biological mechanism of action for disease associated …
Epigenome‐wide study identifies novel methylation loci associated with body mass index and waist circumference
Objective To conduct an epigenome‐wide analysis of DNA methylation and obesity traits.
Methods DNA methylation was quantified in CD4+ T‐cells using the Illumina Infinium …
Methods DNA methylation was quantified in CD4+ T‐cells using the Illumina Infinium …
[HTML][HTML] Global analysis of DNA methylation variation in adipose tissue from twins reveals links to disease-associated variants in distal regulatory elements
E Grundberg, E Meduri, JK Sandling… - The American Journal of …, 2013 - cell.com
Epigenetic modifications such as DNA methylation play a key role in gene regulation and
disease susceptibility. However, little is known about the genome-wide frequency …
disease susceptibility. However, little is known about the genome-wide frequency …
Epigenome-wide association in adipose tissue from the METSIM cohort
Most epigenome-wide association studies to date have been conducted in blood. However,
metabolic syndrome is mediated by a dysregulation of adiposity and therefore it is critical to …
metabolic syndrome is mediated by a dysregulation of adiposity and therefore it is critical to …
DNA methylation and obesity traits: An epigenome-wide association study. The REGICOR study
S Sayols-Baixeras, I Subirana, A Fernández-Sanlés… - Epigenetics, 2017 - Taylor & Francis
Obesity is associated with increased risk of several diseases and has become epidemic.
Obesity is highly heritable but the genetic variants identified by genome-wide association …
Obesity is highly heritable but the genetic variants identified by genome-wide association …
Genome-wide DNA methylation analysis reveals loci that distinguish different types of adipose tissue in obese individuals
D Macartney-Coxson, MC Benton, R Blick… - Clinical …, 2017 - Springer
Background Epigenetic mechanisms provide an interface between environmental factors
and the genome and are known to play a role in complex diseases such as obesity. These …
and the genome and are known to play a role in complex diseases such as obesity. These …
Epigenome-wide profiling of DNA methylation in paired samples of adipose tissue and blood
Many epigenetic association studies have attempted to identify DNA methylation markers in
blood that are able to mirror those in target tissues. Although some have suggested potential …
blood that are able to mirror those in target tissues. Although some have suggested potential …
Personalized epigenomic signatures that are stable over time and covary with body mass index
The epigenome consists of non–sequence-based modifications, such as DNA methylation,
that are heritable during cell division and that may affect normal phenotypes and …
that are heritable during cell division and that may affect normal phenotypes and …
Adipose methylome integrative-omic analyses reveal genetic and dietary metabolic health drivers and insulin resistance classifiers
C Christiansen, M Tomlinson, M Eliot, E Nilsson… - Genome medicine, 2022 - Springer
Background There is considerable evidence for the importance of the DNA methylome in
metabolic health, for example, a robust methylation signature has been associated with …
metabolic health, for example, a robust methylation signature has been associated with …
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