Little is known about the extent to which interactions between genetics and epigenetics may
affect the risk of complex metabolic diseases and/or their intermediary phenotypes. We …

Genetic variants that associate with DNA methylation at CpG sites (methylation quantitative
trait loci, meQTLs) offer a potential biological mechanism of action for disease associated …

Objective To conduct an epigenome‐wide analysis of DNA methylation and obesity traits.
Methods DNA methylation was quantified in CD4+ T‐cells using the Illumina Infinium …

Epigenetic modifications such as DNA methylation play a key role in gene regulation and
disease susceptibility. However, little is known about the genome-wide frequency …

Most epigenome-wide association studies to date have been conducted in blood. However,
metabolic syndrome is mediated by a dysregulation of adiposity and therefore it is critical to …

Obesity is associated with increased risk of several diseases and has become epidemic.
Obesity is highly heritable but the genetic variants identified by genome-wide association …

Background Epigenetic mechanisms provide an interface between environmental factors
and the genome and are known to play a role in complex diseases such as obesity. These …

Many epigenetic association studies have attempted to identify DNA methylation markers in
blood that are able to mirror those in target tissues. Although some have suggested potential …

The epigenome consists of non–sequence-based modifications, such as DNA methylation,
that are heritable during cell division and that may affect normal phenotypes and …

Background There is considerable evidence for the importance of the DNA methylome in
metabolic health, for example, a robust methylation signature has been associated with …