[HTML][HTML] Puerarin promoted proliferation and differentiation of dopamine-producing cells in Parkinson's animal models

L Shiying, Q Xinhui, J Guanghua, N Feng… - Biomedicine & …, 2018 - Elsevier
Background Parkinson's disease (PD) is caused by the gradual loss of dopamine-producing
cells in the brain. This study evaluated the potential neuroprotective role of puerarin (PR) on …

Puerarin protects dopaminergic neurons in Parkinson's disease models

X Zhang, J Xiong, S Liu, L Wang, J Huang, L Liu… - Neuroscience, 2014 - Elsevier
It has been acknowledged that oxidative stress, resulting in the apoptosis of dopaminergic
neurons, is a key mechanism in the pathogenesis of Parkinson's disease (PD). Puerarin …

[PDF][PDF] Puerarin prevents inflammation and apoptosis in the neurocytes of a murine Parkinson's disease model

M Jiang, Q Yun, G Niu, Y Gao, F Shi, S Yu - Genet Mol Res, 2016 - m.jstshuichan.com
The aim of this study was to investigate Parkinson's disease (PD) using a murine model of
PD. Specifically, we aimed to explore the mechanism by which puerarin prevents …

[HTML][HTML] Transplantation of Deprenyl-Induced Tyrosine Hydroxylase-Positive Cells Improves 6-OHDA-Lesion Rat Model of Parkinson's Disease: Behavioral and …

MHG Kashani, MT Ghorbanian… - Cell Journal …, 2013 - ncbi.nlm.nih.gov
Objective: There is longstanding experimental and clinical evidence that supports the idea
that replacement of dopaminergic (DAergic) neurons can ameliorate functional disabilities of …

Puerarin protects dopaminergic neurons against 6-hydroxydopamine neurotoxicity via inhibiting apoptosis and upregulating glial cell line-derived neurotrophic factor …

G Zhu, X Wang, Y Chen, S Yang, H Cheng… - Planta …, 2010 - thieme-connect.com
Neurodegeneration is one of the primary etiologies in the onset of Parkinson's disease. In
the quest for a new antiparkinsonism treatment the potential benefits of puerarin from the …

Transplantation of Deprenyl-Induced Tyrosine Hydroxylase-Positive Cells Improves 6-OHDA-Lesion Rat Model of Parkinson's Disease: Behavioral and …

GKM HAJI, MT Ghorbanian, L Hosseinpour - 2013 - sid.ir
Objective: There is longstanding experimental and clinical evidence that supports the idea
that replacement of dopaminergic (DAergic) neurons can ameliorate functional disabilities of …

[HTML][HTML] Pharmacological mechanisms of puerarin in the treatment of Parkinson's disease: An overview

N Zhang, P Guo, Y Zhao, X Qiu, S Shao, Z Liu… - Biomedicine & …, 2024 - Elsevier
Puerarin, a monomer of traditional Chinese medicine, is a key component of Pueraria radix.
Both clinical and experimental researches demonstrated that puerarin has therapeutic …

Neuroprotective effects of puerarin on 1‐methyl‐4‐phenyl‐1, 2, 3, 6‐tetrahydropyridine induced Parkinson's disease model in mice

G Zhu, X Wang, S Wu, X Li, Q Li - Phytotherapy Research, 2014 - Wiley Online Library
Puerarin, an active component of Pueraria montana var. lobata (Willd.) Sanjappa & Pradeep
is well‐known for its anti‐oxidative and neuroprotective activities. Although anti‐Parkinson's …

[HTML][HTML] Proliferation and committed differentiation into dopamine neurons of neural stem cells induced by the active ingredients of radix astragali

H Gao, L Dou, L Shan, Y Sun, W Li - Neuroreport, 2018 - journals.lww.com
Neural stem cells (NSCs) are important cellular sources of transplantation therapies for
Parkinson's disease. This study aimed to determine the effects of extracts of radix astragali …

[HTML][HTML] Protective effect of puerarin against oxidative stress injury of neural cells and related mechanisms

Y Cheng, W Leng, J Zhang - Medical Science Monitor: International …, 2016 - ncbi.nlm.nih.gov
Background Parkinson's disease (PD) is manifested as degeneration of dopaminergic
neurons in substantia nigra compacta. The mitochondrial dysfunction induced by oxidative …