Phase 3 trial of a small-volume subcutaneous 6-month duration leuprolide acetate treatment for central precocious puberty

KO Klein, A Freire, MG Gryngarten… - The Journal of …, 2020 - academic.oup.com
Context Gonadotropin-releasing hormone agonists (GnRHas) are standard of care for
central precocious puberty (CPP). A 6-month subcutaneous injection has recently been …

Central precocious puberty: an overview of diagnosis, treatment, and outcome

PA Lee - Endocrinology and metabolism clinics of North America, 1999 - Elsevier
This article presents the author's perspective on the diagnosis of central precocious puberty
(CPP) and its treatment with gonadotropin-releasing hormone (GnRH) analogues. Recent …

Challenges and controversies in diagnosis and management of gonadotropin dependent precocious puberty: an Indian perspective

M Kumar, S Mukhopadhyay, D Dutta - Indian Journal of …, 2015 - journals.lww.com
Managing precocious puberty (PP) has been a challenge due to lack of standardized
definition, gonadotrophins assay, gonadotrophin stimulation, timings for blood sampling …

The diagnostic utility of the basal luteinizing hormone level and single 60-minute post GnRH agonist stimulation test for idiopathic central precocious puberty in girls

R Cao, J Liu, P Fu, Y Zhou, Z Li, P Liu - Frontiers in Endocrinology, 2021 - frontiersin.org
Objective The present study aimed to assess the diagnostic utility of the Luteinizing hormone
(LH) levels and single 60-minute post gonadotropin-releasing hormone (GnRH) agonist …

High diagnostic accuracy of subcutaneous T riptorelin test compared with Gn RH test for diagnosing central precocious puberty in girls

AV Freire, ME Escobar, MG Gryngarten… - Clinical …, 2013 - Wiley Online Library
Summary Context The G n RH test is the gold standard to confirm the diagnosis of central
precocious puberty (CPP); however, this compound is not always readily available …

Three-month sustained-release triptorelin (11.25 mg) in the treatment of central precocious puberty

JC Carel, J Blumberg, C Seymour… - European journal of …, 2006 - academic.oup.com
Abstract Objective Depot GnRH agonists are commonly used in the treatment of central
precocious puberty (CPP). The triptorelin 11.25 mg 3-month depot, currently used in adult …

Changing etiological trends in male precocious puberty: evaluation of 100 cases with central precocious puberty over the last decade

A Alikasifoglu, D Vuralli, EN Gonc, A Ozon… - Hormone research in …, 2015 - karger.com
Background/Aims: There are few studies in the literature that have evaluated the etiological
factors in boys with central precocious puberty (CPP), and these studies are limited in terms …

Use of local data to enhance uptake of published recommendations: an example from the diagnostic evaluation of precocious puberty

J Harrington, MR Palmert, J Hamilton - Archives of disease in …, 2014 - adc.bmj.com
Background It has been recommended that basal luteinising hormone (LH) levels be used
as the initial test to identify cases of central precocious puberty (CPP) in children. However …

Treatment of central precocious puberty

EA Eugster - Journal of the Endocrine Society, 2019 - academic.oup.com
Long-acting analogs of GnRH (GnRHas) have been the gold-standard treatment of central
precocious puberty (CPP) worldwide and have an enviable track record of safety and …

Subcutaneous gonadotropin-releasing hormone agonist (triptorelin) test for diagnosing precocious puberty

P Poomthavorn, P Khlairit, P Mahachoklertwattana - Hormone research, 2009 - karger.com
Background: A test involving 100 μg of intravenous gonadotropin-releasing hormone
(GnRH) is a gold standard for confirming the diagnosis of central precocious puberty (CPP) …