Membrane transport ofglucose and intracellular phosphorylation of the sugar are both
accelerated by anoxia in the perfused isolated rat heart (Morgan, Randle & Regen, 1959). In …

We have modeled the energy metabolism of the perfused rat heart in order to elucidate the
interaction of physiological and biochemical control mechanisms. This model which includes …

During a 15-minute period of myocardial ischemia, glycogen concentration fell. This
decrease was roughly accounted for by increases in hexosemonophosphate and lactic acid …

The phosphorylation of glucose is inhibited in heart (Morgan et al., 1959), skeletal muscle
(Kipnis and Cori, 1960), and liver (Chernick et al., 1951; Renold et al., 1954) of diabetic rats …

Publisher Summary The Pasteur effect can be defined in two parts:(1) as the action of
oxygen in diminishing the carbohydrate uptake and its catabolism;(2) as the action of …

1. Transient and steady-state changes caused by acetate utilization were studied in
perfused rat heart. The transient period occupied 6min and steady-state changes were …

In normoxic conditions, myocardial glucose utilization is inhibited when alternative
oxidizable substrates are available. In this work we show that this inhibition is relieved in the …

A number of reports in the literature indicate that phosphofructokinase plays an important
role in the regulation of glycolysis in the cell (l-3). Lardy and Parks (4) reported that an …

1. The ability of tricarboxylic acid-cycle metabolites to influence the physiological
performance of the perfused anaerobic rat heart was investigated. Energy expenditure/h …

A method has been developed to specifically measure fructose-2, 6-bisphosphate in tissues.
After elimination of the hexose-6-phosphate present in the extract, fructose-2, 6 …