Background & aims For more than eight decades, cardiovascular disease (CVD) has
remained the leading cause of death in the world. CVD risk factors are multifaceted, with …

Background Cardiometabolic diseases are complex traits which are influenced by several
single nucleotide polymorphisms (SNPs). Thus, analysing the combined effects of multiple …

Abstract Aims Genetic risk scores (GRSs) have been associated with coronary heart disease
(CHD) in large studies. We asked whether expanding an established 27-variant GRS …

Background—Cardiovascular risk factors tend to aggregate. The biological and predictive
value of this aggregation is questioned and genetics could shed light on this debate. Our …

Objectives An additive genetic risk score (GRS) for coronary heart disease (CHD) has
previously been associated with incident CHD in the population-based Greek European …

Background—There are several well-established lifestyle factors influencing dyslipidemia
and currently; 157 genetic susceptibility loci have been reported to be associated with serum …

Background There is growing support for the use of genetic risk scores (GRS) in routine
clinical settings. Due to the limited diversity of current genomic discovery samples, there are …

Background Both body mass index (BMI) and genetic factors independently contribute to
cardiovascular disease (CVD). However, it is unclear whether genetic risk modifies the …

Objective—To investigate the associations between obesity-predisposing genetic variants,
cardiovascular biomarkers, and cardiovascular disease (CVD) risk in women with …

Background: Using a genetic risk score (GRS) to predict coronary heart disease (CHD) may
detect disease earlier. The current study aims to assess whether GRS is associated with …