Background The microbiome is essential for normal myenteric intrinsic primary afferent
neuron (IPAN) excitability. These neurons control gut motility and modulate gut–brain …

Background The role of intestinal microbiota in the development and function of host
physiology is of high interest, especially with respect to the nervous system. While strong …

Background and aims As the importance of gut–brain interactions increases, understanding
how specific gut microbes interact with the enteric nervous system (ENS), which is the first …

Background The intestinal microbiota plays an important role in regulating gastrointestinal
(GI) physiology in part through interactions with the enteric nervous system (ENS) …

An intact gut epithelium preserves the immunological exclusion of “non-self” entities in the
external environment of the gut lumen. Nonetheless, information flows continuously across …

Trillions of bacteria reside within our gastrointestinal tract, ideally forming a mutually
beneficial relationship between us. However, persistent changes in diet and lifestyle in the …

Background & Aims Reduced gastrointestinal (GI) motility is a feature of disorders
associated with intestinal dysbiosis and loss of beneficial microbes. It is not clear how …

Background & Aims Although chronic diarrhea and constipation are common, the treatment
is symptomatic because their pathophysiology is poorly understood. Accumulating evidence …

The period during and immediately after weaning is an important developmental window
when marked shifts in gut microbiota can regulate the maturation of the enteric nervous …

Many essential gastrointestinal functions, including motility, secretion, and blood flow, are
regulated by the autonomic nervous system (ANS), both through intrinsic enteric neurons …