Implantable powder-carrying microneedles for transdermal delivery of high-dose insulin with enhanced activity

S Kim, H Yang, J Eum, Y Ma, SF Lahiji, H Jung - Biomaterials, 2020 - Elsevier
Recently, numerous transdermal drug delivery systems have been developed for safe and
efficient delivery of biopharmaceuticals. Dissolving microneedles (DMNs) are one such drug …

Dissolving polymer microneedles for transdermal delivery of insulin

N Zhang, X Zhou, L Liu, L Zhao, H Xie… - Frontiers in …, 2021 - frontiersin.org
It's of great significance to develop insulin-loaded dissolving microneedles (MNs) which are
fabricated with various methods and materials for transdermal delivery of insulin to …

Formulation of two‐layer dissolving polymeric microneedle patches for insulin transdermal delivery in diabetic mice

IC Lee, WM Lin, JC Shu, SW Tsai… - … research Part A, 2017 - Wiley Online Library
Dissolving microneedles (MNs) display high efficiency in delivering poorly permeable drugs
and vaccines. Here, two‐layer dissolving polymeric MN patches composed of gelatin and …

In vitro and in vivo assessment of polymer microneedles for controlled transdermal drug delivery

BZ Chen, M Ashfaq, XP Zhang, JN Zhang… - Journal of Drug …, 2018 - Taylor & Francis
Microneedles (MNs) system for transdermal drug delivery has the potential to improve
therapeutic efficacy, proving an approach that is more convenient and acceptable than …

A novel method for fabrication of coated microneedles with homogeneous and controllable drug dosage for transdermal drug delivery

BZ Chen, MC He, XP Zhang, WM Fei, Y Cui… - Drug Delivery and …, 2022 - Springer
Over the years, scientists have been focused on the development of microneedle coating
process to coat a broad range of therapeutic agents onto the surface of the solid …

Dissolving microneedle patches for transdermal insulin delivery in diabetic mice: potential for clinical applications

CH Chen, VBH Shyu, CT Chen - Materials, 2018 - mdpi.com
In this study, dissolving polymeric microneedle (MN) patches composed of gelatin and
sodium carboxymethyl cellulose (CMC) were used to localize insulin. Their in vitro skin …

Fabrication of composite microneedles integrated with insulin-loaded CaCO3 microparticles and PVP for transdermal delivery in diabetic rats

D Liu, B Yu, G Jiang, W Yu, Y Zhang, B Xu - Materials Science and …, 2018 - Elsevier
Dissolving microneedles (MNs) display high efficiency, safety and painless in transdermal
delivery for poorly permeable drugs. Here, a dissolving composite MNs prepared from …

Fabrication of two-layer dissolving polyvinylpyrrolidone microneedles with different molecular weights for in vivo insulin transdermal delivery

IC Lee, YC Wu, SW Tsai, CH Chen, MH Wu - Rsc Advances, 2017 - pubs.rsc.org
Transdermal drug delivery is a convenient route to transport pharmaceuticals. However, its
application is limited to a few compounds. Microneedle (MN) patches have demonstrated a …

A patchless dissolving microneedle delivery system enabling rapid and efficient transdermal drug delivery

SF Lahiji, M Dangol, H Jung - Scientific reports, 2015 - nature.com
Dissolving microneedles (DMNs) are polymeric, microscopic needles that deliver
encapsulated drugs in a minimally invasive manner. Currently, DMN arrays are …

A self-adherent, bullet-shaped microneedle patch for controlled transdermal delivery of insulin

KY Seong, MS Seo, DY Hwang, ED O'Cearbhaill… - Journal of Controlled …, 2017 - Elsevier
Proteins are important biologic therapeutics used for the treatment of various diseases.
However, owing to low bioavailability and poor skin permeability, transdermal delivery of …