Implantable powder-carrying microneedles for transdermal delivery of high-dose insulin with enhanced activity
Recently, numerous transdermal drug delivery systems have been developed for safe and
efficient delivery of biopharmaceuticals. Dissolving microneedles (DMNs) are one such drug …
efficient delivery of biopharmaceuticals. Dissolving microneedles (DMNs) are one such drug …
Dissolving polymer microneedles for transdermal delivery of insulin
N Zhang, X Zhou, L Liu, L Zhao, H Xie… - Frontiers in …, 2021 - frontiersin.org
It's of great significance to develop insulin-loaded dissolving microneedles (MNs) which are
fabricated with various methods and materials for transdermal delivery of insulin to …
fabricated with various methods and materials for transdermal delivery of insulin to …
Formulation of two‐layer dissolving polymeric microneedle patches for insulin transdermal delivery in diabetic mice
Dissolving microneedles (MNs) display high efficiency in delivering poorly permeable drugs
and vaccines. Here, two‐layer dissolving polymeric MN patches composed of gelatin and …
and vaccines. Here, two‐layer dissolving polymeric MN patches composed of gelatin and …
In vitro and in vivo assessment of polymer microneedles for controlled transdermal drug delivery
Microneedles (MNs) system for transdermal drug delivery has the potential to improve
therapeutic efficacy, proving an approach that is more convenient and acceptable than …
therapeutic efficacy, proving an approach that is more convenient and acceptable than …
A novel method for fabrication of coated microneedles with homogeneous and controllable drug dosage for transdermal drug delivery
Over the years, scientists have been focused on the development of microneedle coating
process to coat a broad range of therapeutic agents onto the surface of the solid …
process to coat a broad range of therapeutic agents onto the surface of the solid …
Dissolving microneedle patches for transdermal insulin delivery in diabetic mice: potential for clinical applications
CH Chen, VBH Shyu, CT Chen - Materials, 2018 - mdpi.com
In this study, dissolving polymeric microneedle (MN) patches composed of gelatin and
sodium carboxymethyl cellulose (CMC) were used to localize insulin. Their in vitro skin …
sodium carboxymethyl cellulose (CMC) were used to localize insulin. Their in vitro skin …
Fabrication of composite microneedles integrated with insulin-loaded CaCO3 microparticles and PVP for transdermal delivery in diabetic rats
Dissolving microneedles (MNs) display high efficiency, safety and painless in transdermal
delivery for poorly permeable drugs. Here, a dissolving composite MNs prepared from …
delivery for poorly permeable drugs. Here, a dissolving composite MNs prepared from …
Fabrication of two-layer dissolving polyvinylpyrrolidone microneedles with different molecular weights for in vivo insulin transdermal delivery
IC Lee, YC Wu, SW Tsai, CH Chen, MH Wu - Rsc Advances, 2017 - pubs.rsc.org
Transdermal drug delivery is a convenient route to transport pharmaceuticals. However, its
application is limited to a few compounds. Microneedle (MN) patches have demonstrated a …
application is limited to a few compounds. Microneedle (MN) patches have demonstrated a …
A patchless dissolving microneedle delivery system enabling rapid and efficient transdermal drug delivery
Dissolving microneedles (DMNs) are polymeric, microscopic needles that deliver
encapsulated drugs in a minimally invasive manner. Currently, DMN arrays are …
encapsulated drugs in a minimally invasive manner. Currently, DMN arrays are …
A self-adherent, bullet-shaped microneedle patch for controlled transdermal delivery of insulin
KY Seong, MS Seo, DY Hwang, ED O'Cearbhaill… - Journal of Controlled …, 2017 - Elsevier
Proteins are important biologic therapeutics used for the treatment of various diseases.
However, owing to low bioavailability and poor skin permeability, transdermal delivery of …
However, owing to low bioavailability and poor skin permeability, transdermal delivery of …
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