Macrophage polarization plays an essential role in cardiac remodeling after injury, evolving
from an initial accumulation of proinflammatory M1 macrophages to a greater balance of anti …

Even with recent advances in care, heart failure remains a major cause of morbidity and
mortality, which urgently needs new treatments. One of the major antecedents of heart …

Paradigm-shifting studies in the mouse have identified tissue macrophage heterogeneity as
a critical determinant of immune responses. In contrast, surprisingly little is known regarding …

Background Inflammation is induced in the heart during the development of cardiac
hypertrophy. The initiating mechanisms and the role of inflammation in cardiac hypertrophy …

Aims The goal of this study was to characterize the role of inflammatory macrophages in the
induction of the vascular smooth muscle cell (VSMC)-mediated formation of aortic tertiary …

Aims: The lymphatic system is involved in fluid homeostasis of the cardiac interstitium, but
lymphangiogenesis in myocardial remodelling has not previously been examined …

The lymphatic system is a key component of tissue fluid homeostasis. In contrast to the
closed and high-pressure blood vascular system, the lymphatic vascular system transports …

Aim Lymphatic vessels are of special importance for tissue homeostasis, and increases of
their density may foster tissue regeneration. Exercise could be a relevant tool to increase …

Impairment of the lymphatic system is apparent in multiple inflammatory pathologies
connected to elevated endotoxins such as LPS. However, the direct mechanisms by which …

The adult heart has been reported to have an extensive lymphatic system, yet the
development of this important system during cardiogenesis is still largely unexplored. The …