Photons, such as X-or γ-rays, induce DNA damage (distributed throughout the nucleus) as a
result of low-density energy deposition. In contrast, particle irradiation with high linear …

DNA double-strand breaks (DSBs) induced by ionising radiation are considered the major
cause of genotoxic mutations and cell death. While DSBs are dispersed throughout …

Low-linear energy transfer (LET) radiation (ie, γ-and X-rays) induces DNA double-strand
breaks (DSBs) that are rapidly repaired (rejoined). In contrast, DNA damage induced by the …

Clustered DNA damage is related to the biological effects of ionizing radiation. However, its
precise yield and complexity (ie, number of lesions per damaged site) in vivo remain …

Increasing use of heavy ions for cancer therapy and concerns from exposure to heavy
charged particles in space necessitate the study of the basic biological mechanisms …

Cells exposed to densely ionizing radiation (high-LET) experience more severe biological
damage than do cells exposed to sparsely ionizing radiation (low-LET). The prevailing …

Abstract Prise, KM, Pinto, M., Newman, HC and Michael, BD A Review of Studies of Ionizing
Radiation-Induced Double-Strand Break Clustering. Radiat. Res. 156, 572–576 (2001) …

Low-and high-linear energy transfer (LET) ionising radiation are effective cancer therapies,
but produce structurally different forms of DNA damage. Isolated DNA damage is repaired …

Clustered DNA damage is a specific type of DNA damage induced by ionizing radiation. Any
type of ionizing radiation traverses the target DNA molecule as a beam, inducing damage …

High-linear-energy-transfer (LET) radiation is more lethal than similar doses of low-LET
radiation types, probably a result of the condensed energy deposition pattern of high-LET …