Aberrant hippocampal neurogenesis contributes to learning and memory deficits in a mouse model of repetitive mild traumatic brain injury

K Greer - 2019 - vtechworks.lib.vt.edu
Adult hippocampal neurogenesis, or the process of creating new neurons in the dentate
gyrus (DG) of the hippocampus, underlies learning and memory capacity. This cognitive …

[PDF][PDF] Activation of Early Neural Progenitors Is Required for Traumatic Brain Injury-Induced Hippocampal Neurogenesis

TS Yu - 2008 - utswmed-ir.tdl.org
Traumatic brain injury (TBI) is the most common form of acquired brain injury in both children
and adults in the United States. TBI causes neuronal loss and results in a variety of …

[HTML][HTML] Abrogation of atypical neurogenesis and vascular-derived EphA4 prevents repeated mild TBI-induced learning and memory impairments

K Greer, EKG Basso, C Kelly, A Cash, E Kowalski… - Scientific Reports, 2020 - nature.com
Brain injury resulting from repeated mild traumatic insult is associated with cognitive
dysfunction and other chronic co-morbidities. The current study tested the effects of aberrant …

The absence of a neurogenic response to a repeated concussive-like injury in mice

A Weingarten, TM Madjou, SN Yeturu, N Samudrala… - bioRxiv, 2023 - biorxiv.org
In response to traumatic brain injury (TBI), the brain increases its generation of new neurons
(neurogenesis) within the hippocampus, a brain region critical for learning and memory …

[HTML][HTML] Mild traumatic brain injury induces transient, sequential increases in proliferation, neuroblasts/immature neurons, and cell survival: a time course study in the …

LR Clark, S Yun, NK Acquah, PL Kumar… - Frontiers in …, 2021 - frontiersin.org
Mild traumatic brain injuries (mTBIs) are prevalent worldwide. mTBIs can impair
hippocampal-based functions such as memory and cause network hyperexcitability of the …

Functional integration of adult-born hippocampal neurons after traumatic brain injury

LE Villasana, KN Kim, GL Westbrook, E Schnell - eneuro, 2015 - eneuro.org
Traumatic brain injury (TBI) increases hippocampal neurogenesis, which may contribute to
cognitive recovery after injury. However, it is unknown whether TBI-induced adult-born …

Traumatic brain injury and hippocampal neurogenesis: Functional implications

JB Redell, ME Maynard, EL Underwood, SM Vita… - Experimental …, 2020 - Elsevier
In the adult brain, self-renewing radial-glia like (RGL) progenitor cells have been shown to
reside in the subventricular zone and the subgranular zone of the hippocampus. A large …

Neurologic impairment following closed head injury predicts post-traumatic neurogenesis

LE Villasana, GL Westbrook, E Schnell - Experimental neurology, 2014 - Elsevier
In the mammalian hippocampus, neurogenesis persists into adulthood, and increased
generation of newborn neurons could be of clinical benefit following concussive head …

Temporally specified genetic ablation of neurogenesis impairs cognitive recovery after traumatic brain injury

CA Blaiss, TS Yu, G Zhang, J Chen… - Journal of …, 2011 - Soc Neuroscience
Significant spontaneous recovery occurs after essentially all forms of serious brain injury,
although the mechanisms underlying this recovery are unknown. Given that many forms of …

Temporal Analysis of Neurogenesis and Microglia Changes after Mild Traumatic Brain Injury in the Adult Male C57BL/6J Mouse

LR Clark - 2021 - search.proquest.com
Traumatic brain injury (TBI) affects millions of people every year. Injuries can have a range
of severities from mild to severe, but all injuries have the potential to result in lasting …