Studies of CD8 T cell responses to vaccination or infection with various pathogens in both
animal models and human subjects have revealed a markedly consistent array of age …

Memory T cells that are specific for one virus can become activated during infection with an
unrelated heterologous virus, and might have roles in protective immunity and …

In acute infectious mononucleosis (AIM), very large clones of Ag-specific CD8+ effector T
cells are generated. Many clones persist as memory cells, although the clone size is greatly …

The developmental origins of memory T cells remain incompletely understood. During the
expansion phase of acute viral infection, we identified a distinct subset of virus-specific …

Memory CD8 T cells acquire effector memory cell properties after reinfection and may reach
terminally differentiated, senescent states (“Hayflick limit”) after multiple infections. The …

Infection or vaccination confers heightened resistance to pathogen rechallenge because of
quantitative and qualitative differences between naive and primary memory T cells. Herein …

T cell memory is a cornerstone of protective immunity, and is the key element in successful
vaccination. Upon encountering the relevant pathogen, memory T cells are thought to initiate …

Failure to clear persistent viral infections results from the early loss of T cell activity. A
pertinent question is whether the immune response is programmed to fail or if …

CD8 effector T cells with a CD127 hi KLRG1− phenotype are considered precursors to the
long-lived memory pool, whereas KLRG1+ CD127 low cells are viewed as short-lived …

During infection, CD8+ T cells not only respond to antigenic signals through their T cell
receptor (TCR) but also incorporate inflammatory signals from cytokines produced in the …