After viral infection, naive CD8+ T cells become activated and either differentiate into effector
cells, which eliminate virus-infected cells, or convert to memory-type T cells, awaiting re …

We have investigated the contribution of CD4 T cells to the optimal priming of functionally
robust memory CD8 T cell subsets. Intranasal infection of CD4 T cell-deficient (CD4−/−) mice …

In response to infection, antigen‐specific CD8+ T cells undergo massive expansion in
numbers, acquire effector mechanisms, and disseminate throughout the body. The …

During chronic infection, pathogen-specific CD8+ T cells upregulate expression of
molecules such as the inhibitory surface receptor PD-1, have diminished cytokine …

The role of CD4 T cells in providing help to CD8 T cells in primary and secondary responses
to infection remains controversial. Using recombinant strains of virus and bacteria …

Disruption of T cell memory during severe immune suppression results in reactivation of
chronic viral infections, such as Epstein Barr virus (EBV) and Cytomegalovirus (CMV). How …

In this study, we examined the cytotoxic activity of effector and memory CD8 T cells in vivo.
At the peak of the CTL response following an acute lymphocytic choriomeningitis virus …

Peripheral T cell diversity is virtually constant in the young, but is invariably reduced in aged
mice and humans. CD8+ T cell clonal expansions (TCE) are the most drastic manifestation …

A critical aim of vaccine‐related research is to identify the mechanisms by which memory T
cells are formed and maintained over long periods of time. In recent years, we have …

Viral persistence specifically inhibits CD4 Th1 responses and promotes Tfh immunity, but
the mechanisms that suppress Th1 cells and the disease consequences of their loss are …