Generation of memory T cells, which mediate immunity against microbes and cancers,
relies, for optimal activity, on the interactions of multiple cell types that are highly regulated …

Models of the differentiation of memory CD8+ T cells that replicate during secondary
infections differ over whether such cells had acquired effector function during primary …

A basic principle of immunology is that prior immunity results in complete protection against
a homologous agent. In this study, we show that memory T cells specific to unrelated viruses …

We use mathematical models to analyze the role of a memory cytotoxic T lymphocyte (CTL)
response in viral infections. The model predicts that antigen-independent persistence of an …

Repeated antigenic encounter drives proliferation and differentiation of memory T cell pools.
An important question is whether certain specific T cells may be driven eventually to …

Chronic viral infections often result in ineffective CD8 T-cell responses due to functional
exhaustion or physical deletion of virus-specific T cells. However, how persisting virus …

Whether tissue microenvironment influences memory CD8 T cell differentiation is unclear.
We demonstrate that virus-specific intraepithelial lymphocytes in gut resemble neither …

Both αβ and γδ T‐cell populations and natural killer (NK) cells include cytotoxic, interferon
(IFN)‐γ‐producing lymphocytes that actively respond to viral infections. We show here that …

Memory CD8+ T cells are critical for host defense upon reexposure to intracellular
pathogens. We found that interleukin 10 (IL-10) derived from CD4+ regulatory T cells (Treg …

For acute self-limiting infections a vaccine is successful if it elicits memory at least as good
as the natural experience; however, for persistent and chronic infections such as HIV …