Gene expression profiling has reshaped our understanding of breast cancer by identifying
four molecular subtypes:(1) luminal A,(2) luminal B,(3) human epidermal growth factor …

Gene expression profiling with breast carcinomas has allowed further classification of these
tumors into 5 distinct subtypes (luminal A, luminal B, HER2-overexpression, basal-like, and …

Recently, clinical trials have demonstrated promising efficacy for novel HER2-targeted
therapies in HER2-low breast cancers, raising the prospect of including a HER2-low …

Immunohistochemical markers are often used to classify breast cancer into subtypes that are
biologically distinct and behave differently. The aim of this study was to estimate relapse for …

The objective of this study is to define the survival outcomes associated with distinct
molecular phenotypes defined by immunohistochemical staining of paraffin-embedded …

Breast cancer is a genetically and clinically heterogeneous disease with multiple subtypes.
The classification of these subtypes has evolved over the years. The most common and …

Rationale and Objective Breast cancer can be divided into four major molecular subtypes
based on the expression of hormone receptor (estrogen receptor and progesterone …

Background The clinical impact of the biological heterogeneity within HER2-positive
(HER2+) breast cancer is not fully understood. Here, we evaluated the molecular features …

Abstract HER2-positive (HER2+) breast cancer (BC) is a heterogenous and multifaceted
disease, with interesting therapeutic implications. First, all intrinsic molecular subtypes can …

Estrogen receptor (ER)-positive breast cancer is the most prevalent subtype of invasive
breast cancers. Patients with ER-positive breast cancers have variable clinical outcomes …