[PDF][PDF] BBA-Reviews on Cancer
J Pastwinska, I Karwaciak, K Karas, RA Bachorz… - carcinogenesis - researchgate.net
ABSTRACT RORγT is a transcription factor that directs the development of Th17
lymphocytes and other IL-17-expressing cells (eg, Tc17 and ILC3 cells). These cells are …
lymphocytes and other IL-17-expressing cells (eg, Tc17 and ILC3 cells). These cells are …
[HTML][HTML] RORγT agonists as immune modulators in anticancer therapy.
RORγT is a transcription factor that directs the development of Th17 lymphocytes and other
IL-17-expressing cells (eg, Tc17 and ILC3 cells). These cells are involved in the body's …
IL-17-expressing cells (eg, Tc17 and ILC3 cells). These cells are involved in the body's …
Synthetic RORγt agonists enhance protective immunity
MR Chang, V Dharmarajan, C Doebelin… - ACS chemical …, 2016 - ACS Publications
The T cell specific RORγ isoform RORγt has been shown to be the key lineage-defining
transcription factor to initiate the differentiation program of TH17 and TC17 cells, cells that …
transcription factor to initiate the differentiation program of TH17 and TC17 cells, cells that …
Rationally designed, conformationally constrained inverse agonists of RORγt—identification of a potent, selective series with biologic-like in vivo efficacy
D Marcoux, JJW Duan, Q Shi, RJ Cherney… - Journal of Medicinal …, 2019 - ACS Publications
RORγt is an important nuclear receptor that regulates the production of several pro-
inflammatory cytokines such as IL-17 and IL-22. As a result, RORγt has been identified as a …
inflammatory cytokines such as IL-17 and IL-22. As a result, RORγt has been identified as a …
Small molecule allosteric inhibitors of RORγt block Th17-dependent inflammation and associated gene expression in vivo
SA Saenz, A Local, T Carr, A Shakya, S Koul, H Hu… - Plos one, 2021 - journals.plos.org
Retinoic acid receptor-related orphan nuclear receptor (ROR) γt is a member of the RORC
nuclear hormone receptor family of transcription factors. RORγt functions as a critical …
nuclear hormone receptor family of transcription factors. RORγt functions as a critical …
Pharmacological inhibition of ROR gamma t suppresses the Th17 pathway and alleviates antigen-induced arthritis in-vivo
U Guendisch, J Weiss, F Ecoeur, J Riker… - PLoS …, 2017 - oak.novartis.com
Retinoic acid receptor-related-orphan-receptor-C (ROR gammat) is the key transcription
factor that is driving the differentiation of IL-17 producing T-helper 17 (Th17) cells that are …
factor that is driving the differentiation of IL-17 producing T-helper 17 (Th17) cells that are …
The emerging landscape of RORγt biology
JS Lee, DJ Cua - Immunity, 2014 - cell.com
The transcription factor retinoid-related orphan receptor gamma t (RORγt) has emerged as
an exciting target for inflammatory diseases. Xiao et al.(2014) show that a new class of …
an exciting target for inflammatory diseases. Xiao et al.(2014) show that a new class of …
[HTML][HTML] Post-translational regulation of RORγt—A therapeutic target for the modulation of interleukin-17-mediated responses in autoimmune diseases
Retinoic acid-related orphan receptor gamma t (RORγt) is a nuclear receptor, which is
selectively expressed by various lymphocytes. RORγt is critical for the development of …
selectively expressed by various lymphocytes. RORγt is critical for the development of …
Discovery of selective RORγ inverse agonists and demonstration of efficacy in inflammatory disease models
RKB Damarla, RK Ujjinamatada, K Nellore… - The Journal of …, 2016 - journals.aai.org
The nuclear hormone receptor RORγ controls the differentiation of Th17 cells that plays a
key pro-inflammatory role in a variety of autoimmune diseases. RORγ inverse agonists from …
key pro-inflammatory role in a variety of autoimmune diseases. RORγ inverse agonists from …
Pharmacological inhibition of RORγt suppresses the Th17 pathway and alleviates arthritis in vivo
U Guendisch, J Weiss, F Ecoeur, JC Riker… - PloS one, 2017 - journals.plos.org
Retinoic acid receptor-related-orphan-receptor-C (RORγt) is the key transcription factor that
is driving the differentiation of IL-17 producing T-helper 17 (Th17) cells that are implicated in …
is driving the differentiation of IL-17 producing T-helper 17 (Th17) cells that are implicated in …