Engineering bioartificial tracheal tissue using hybrid fibroblast-mesenchymal stem cell cultures in collagen hydrogels

H Naito, T Tojo, M Kimura, Y Dohi… - … and thoracic surgery, 2011 - academic.oup.com
We aimed at providing the first in vitro and in vivo proof-of-concept for a novel tracheal tissue
engineering technology. We hypothesized that bioartificial trachea (BT) could be generated …

A novel tissue-engineered trachea with a mechanical behavior similar to native trachea

JH Park, JM Hong, YM Ju, JW Jung, HW Kang, SJ Lee… - Biomaterials, 2015 - Elsevier
A novel tissue-engineered trachea was developed with appropriate mechanical behavior
and substantial regeneration of tracheal cartilage. We designed hollow bellows scaffold as a …

[HTML][HTML] Experimental generation of a tissue-engineered functional and vascularized trachea

T Walles, B Giere, M Hofmann, J Schanz… - The Journal of thoracic …, 2004 - Elsevier
OBJECTIVE: We sought to grow in vitro functional smooth muscle cells, chondrocytes, and
respiratory epithelium on a biologic, directly vascularized matrix as a scaffold for tracheal …

Tissue engineering in the trachea

K Kojima, CA Vacanti - The Anatomical Record, 2014 - Wiley Online Library
This review summarizes efforts to generate an autologous tissue‐engineered trachea (TET)
using various biomaterial or cell sources to make tracheal cartilage to form the structural …

Engineered cartilaginous tubes for tracheal tissue replacement via self-assembly and fusion of human mesenchymal stem cell constructs

AD Dikina, HA Strobel, BP Lai, MW Rolle, E Alsberg - Biomaterials, 2015 - Elsevier
There is a critical need to engineer a neotrachea because currently there are no long-term
treatments for tracheal stenoses affecting large portions of the airway. In this work, a modular …

An ectopic approach for engineering a vascularized tracheal substitute

CK Tsao, CY Ko, SR Yang, CY Yang, EM Brey… - Biomaterials, 2014 - Elsevier
Tissue engineering can provide alternatives to current methods for tracheal reconstruction.
Here we describe an approach for ectopic engineering of vascularized trachea based on the …

[HTML][HTML] A cell-free tissue-engineered tracheal substitute with sequential cytokine release maintained airway opening in a rabbit tracheal full circumferential defect …

Y Liu, K Zheng, Z Meng, L Wang, X Liu, B Guo, J He… - Biomaterials, 2023 - Elsevier
In this study, a cell-free tissue-engineered tracheal substitute was developed, which is
based on a 3D-printed polycaprolactone scaffold coated with a gelatin-methacryloyl (GelMA) …

Tissue-engineered tracheal reconstruction using mesenchymal stem cells seeded on a porcine cartilage powder scaffold

YS Shin, JW Choi, JK Park, YS Kim, SS Yang… - Annals of biomedical …, 2015 - Springer
Tissue engineering using a biocompatible scaffold with various cells might be a solution for
tracheal reconstruction. We investigated the plausibility of using mesenchymal stem cells …

A bioengineered trachea-like structure improves survival in a rabbit tracheal defect model

H Tang, W Sun, X Liu, Q Gao, Y Chen, C Xie… - Science Translational …, 2023 - science.org
A practical strategy for engineering a trachea-like structure that could be used to repair or
replace a damaged or injured trachea is an unmet need. Here, we fabricated bioengineered …

Scaffold-free trachea regeneration by tissue engineering with bio-3D printing

D Taniguchi, K Matsumoto, T Tsuchiya… - … and thoracic surgery, 2018 - academic.oup.com
OBJECTIVES Currently, most of the artificial airway organs still require scaffolds; however,
such scaffolds exhibit several limitations. Alternatively, the use of an autologous artificial …