[HTML][HTML] Lychee seed polyphenol inhibits Aβ-induced activation of NLRP3 inflammasome via the LRP1/AMPK mediated autophagy induction
WQ Qiu, R Pan, Y Tang, XG Zhou, JM Wu, L Yu… - Biomedicine & …, 2020 - Elsevier
Emerging evidence indicates that the enhancement of microglial autophagy inhibits the
NLRP3 inflammasome mediated neuroinflammation in Alzheimer's disease (AD) …
NLRP3 inflammasome mediated neuroinflammation in Alzheimer's disease (AD) …
Lychee seed polyphenol protects the blood–brain barrier through inhibiting Aβ (25–35)‐induced NLRP3 inflammasome activation via the AMPK/mTOR/ULK1 …
R Xiong, XG Zhou, Y Tang, JM Wu… - Phytotherapy …, 2021 - Wiley Online Library
Blood–brain barrier (BBB) dysfunction has been implicated in Alzheimer's disease (AD) and
is closely linked to the release of proinflammatory cytokines in brain capillary endothelial …
is closely linked to the release of proinflammatory cytokines in brain capillary endothelial …
Dihydromyricetin inhibits microglial activation and neuroinflammation by suppressing NLRP 3 inflammasome activation in APP/PS 1 transgenic mice
J Feng, JX Wang, YH Du, Y Liu… - CNS neuroscience & …, 2018 - Wiley Online Library
Background Activated microglia‐mediated inflammation plays a key role in the pathogenesis
of Alzheimer's disease (AD). In addition, chronic activation of NLRP 3 inflammasomes …
of Alzheimer's disease (AD). In addition, chronic activation of NLRP 3 inflammasomes …
[HTML][HTML] A novel treatment strategy by natural products in NLRP3 inflammasome-mediated neuroinflammation in Alzheimer's and Parkinson's disease
JH Lee, HJ Kim, JU Kim, TH Yook, KH Kim… - International journal of …, 2021 - mdpi.com
Alzheimer's disease (AD) and Parkinson's disease (PD) are the most common
neurodegenerative diseases. Many studies have demonstrated that the release of NLRP3 …
neurodegenerative diseases. Many studies have demonstrated that the release of NLRP3 …
[HTML][HTML] Enhanced autolysosomal function ameliorates the inflammatory response mediated by the NLRP3 inflammasome in Alzheimer's disease
W Zhou, D Xiao, Y Zhao, B Tan, Z Long… - Frontiers in Aging …, 2021 - frontiersin.org
The pathogenesis of Alzheimer's disease (AD) involves activation of many NLRP3
inflammatory bodies, which may be related to amyloid β peptide and aggregation of …
inflammatory bodies, which may be related to amyloid β peptide and aggregation of …
[HTML][HTML] Pien-Tze-Huang, a Chinese patent formula, attenuates NLRP3 inflammasome-related neuroinflammation by enhancing autophagy via the AMPK/mTOR/ULK1 …
Z Huang, X Zhou, X Zhang, L Huang, Y Sun… - Biomedicine & …, 2021 - Elsevier
NLRP3 inflammasome is a key mediator in ischemic stroke-induced neuroinflammation and
subsequent brain injury. Our previous study demonstrated the potent activity of Pien-Tze …
subsequent brain injury. Our previous study demonstrated the potent activity of Pien-Tze …
MCC950 reduces autophagy and improves cognitive function by inhibiting NLRP3-dependent neuroinflammation in a rat model of Alzheimer's disease
A Naeem, R Prakash, N Kumari, MA Khan… - Brain, Behavior, and …, 2024 - Elsevier
Alzheimer's disease (AD) is the seventh most common cause of mortality and one of the
major causes of disability and vulnerability in the elderly. AD is characterized by gradual …
major causes of disability and vulnerability in the elderly. AD is characterized by gradual …
Ginkgolide B inhibits NLRP3 inflammasome activation and promotes microglial M2 polarization in Aβ1-42-induced microglia cells
Y Zhang, Y Zhao, J Zhang, Y Gao, S Li, C Chang… - Neuroscience …, 2021 - Elsevier
Nucleotide-binding oligomerization domain (NOD)-like receptor protein 3 (NLRP3)
inflammasome-mediated chronic neuroinflammation plays a crucial role in the progression …
inflammasome-mediated chronic neuroinflammation plays a crucial role in the progression …
Degradation of NLRP3 by p62‐dependent‐autophagy improves cognitive function in Alzheimer's disease by maintaining the phagocytic function of microglia
D Zhang, Y Zhang, J Pan, J Cao, X Sun… - CNS Neuroscience …, 2023 - Wiley Online Library
Background Activation of the NLRP3 inflammasome promotes microglia to secrete
inflammatory cytokines and induce pyroptosis, leading to impaired phagocytic and …
inflammatory cytokines and induce pyroptosis, leading to impaired phagocytic and …
Essential oil of Acorus tatarinowii Schott inhibits neuroinflammation by suppressing NLRP3 inflammasome activation in 3× Tg-AD transgenic mice
Z Xu, X Zhou, X Hong, S Wang, J Wei, J Huang, L Ji… - Phytomedicine, 2023 - Elsevier
Abstract Background Shi chang pu (Acorus tatarinowii Schott) is a herbal used in the
treatment of Alzheimer's disease (AD) in China. The essential oil of Shi chang pu (SCP-oil) …
treatment of Alzheimer's disease (AD) in China. The essential oil of Shi chang pu (SCP-oil) …