Pancreatic islet transplantation has emerged as a therapy for type 1 diabetes and is today
performed using both freshly isolated and cultured islets. Islet blood vessels are disrupted …

Pancreatic islet transplantation is an emerging therapy for type 1 diabetes. To survive and
function, transplanted islets must revascularize because islet isolation severs arterial and …

OBJECTIVE Freshly isolated pancreatic islets contain, in contrast to cultured islets, intraislet
endothelial cells (ECs), which can contribute to the formation of functional blood vessels …

Although the microvascular endothelium has been identified as the primary target site for the
initiation of pancreatic islet graft rejection, little is known of the microvascular and cellular …

Experimental studies indicate low revascularization of intraportally transplanted islets. This
study aimed to quantify, for the first time, the blood perfusion of intrahepatically transplanted …

An adequate revascularization is crucial for islet survival and function after transplantation.
Previous studies have suggested that islet revascularization is concluded within 14 days …

Pancreatic islet transplantation still represents a promising therapeutic strategy for curative
treatment of type 1 diabetes mellitus. However, a limited number of organ donors and …

Aims/hypothesis Recent studies suggest that donor endothelial cells may contribute to islet
graft revascularisation. Since islet endothelial cells disappear during culture, we …

Successful islet transplantation depends on the infusion of sufficiently large quantities of
islets, of which only∼ 30% become stably engrafted. Rapid and adequate revascularization …

Transplantation of pancreatic islets reconstitutes glucose homeostasis in diabetes mellitus.
Before transplantation, islets are disrupted from the surrounding blood vessels by the …